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ORIGINAL ARTICLE
Year : 2019  |  Volume : 14  |  Issue : 2  |  Page : 93-106

Enhanced sustained release of furosemide in long circulating chitosan-conjugated PLGA nanoparticles


1 Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi -221005, India
2 School of Biochemical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi -221005, India
3 Department of Chemical Engineering, Indian Institute of Technology-Delhi, New Delhi-110016, India

Correspondence Address:
Sapna Kashyap
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi -221005
India
Vikas Singh
Department of Chemical Engineering, Indian Institute of Technology-Delhi, New Delhi-110016
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1735-5362.253356

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Furosemide (FSM) is commonly used in the treatment of edema associated with congestive cardiac failure, cirrhosis of the liver, renal disease, including the nephrotic syndrome and hypertension. However, in ascites, it is clinically limited due to its frequent dosing and short biological half-life and its prolonged-release preparations are not available. Therefore, the main objective behind the present research work is to develop chitosan coated and conjugated poly (lactic-co-glycolic acid) (PLGA) nanocarriers, to sustain the delivery of FSM with improved systemic circulation. Emulsion-solvent evaporation technique was used for the preparation of nanoparticles. In-vivo pharmacokinetic study showed 2.6, 3.10, and 4.30 folds enhancement in relative availability of FSM for FSM-PLGA, FSM-chitosan-coated-PLGA and FSM-chitosan-conjugated- PLGA nanoparticles, respectively than FSM. The present research work concluded that FSM loaded chitosan conjugated PLGA nanoparticles could enhance the systemic circulation of FSM with improved pharmacokinetics parameters.


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