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ORIGINAL ARTICLE
Year : 2019  |  Volume : 14  |  Issue : 6  |  Page : 566-573

Naringenin potentiated β-sitosterol healing effect on the scratch wound assay


1 Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, 19328, Amman, Jordan
2 Faculty of Pharmacy, Al-Ahliyya Amman University, 19328, Amman, Jordan

Correspondence Address:
Manal Ahmad Abbas
Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, 19328, Amman
Jordan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1735-5362.272565

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In the present investigation scratch wound assay was used to study the ability of several combinations of each flavonoid (chrysin, naringenin or resveratrol) with β-sitosterol to heal wounds in vitro. MTT test was performed to determine if the combination of flavonoid with β-sitosterol was toxic to fibroblasts or not. Also, superoxide dismutase (SOD) activity and interleukin-1ß (IL-1β) concentrations were measured. The best closure rates were obtained with β-sitosterol combined with naringenin and β-sitosterol combined with resveratrol. The combination that produced the best closure rate namely β-sitosterol with naringenin increased SOD activity significantly. However, this combination was not better than naringenin or β-sitosterol alone in reducing IL-β concentration. The results of MTT test indicated that the combination as well as β-sitosterol alone or naringenin alone has no toxic effect on fibroblasts. In conclusion, the combination of β-sitosterol and naringenin exerted a synergistic effect on wound closure without decreasing the viability of fibroblasts, increased antioxidant defense mechanism and decreased IL-β.


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