Figure 5: Effect of A. indica extract on HMG-CoA reductase activity using in vitro cell-free based assay. A. indica extract at 100 μg/mL or pravastatin 0.25 μM was incubated with HMG-CoA at 400, 800, and 1600 mg/mL. Value represented as mean ± SEM, n = 3. **, *** Indicate significant differences compared with control, P < 0.01 and P < 0.001. ### Shows significant differences in comparison with HMG-CoA at 400 μM, P < 0.001. A. indica, Azadirachta indica; HMG-CoA, 3-hydroxy 3-methylglutaryl-CoA.