Figure 1: Changes in diarrheal status before (day 0) and during 6 days of treatment after induction of colitis (TNBS, 50 mg/kg) in rats. Values are means ± SEM (n = 6). Data are presented as mean ± SEM; * (P < 0.05) and ** (P < 0.01) indicate significant differences compared to TNBS-control group. Stool consistency was checked daily in rats (1, formed stools; 2, loosed stools; and 3, diarrhea). TNBS, 2, 4, 6-trinitrobenzenesulfonic acid; mCPG, metachlorophenylbiguanide.