Figure 1: (A) The effect of NIC plus OVA administration on inflammation score in the lung tissue. The administration of OVA plus NIC at 1 and 10 mg/kg doses could significantly reduce the inflammation in the lung tissue compared to the control group (**P ≤ 0.01) OVA group. # Indicates significant differences compared to the OVA group P ≤ 0.05. B, Conrtol; C, OVA; D, OVA-NIC1; E, OVANIC10; and F, normal group indicate digital images of the lung tissue from different groups. The inflammation significantly reduced in the lung tissue of mice, which received NIC plus OVA compared to the control and OVA groups. The co-administration of 10 mg/kg OVA and NIC significantly reduced the inflammation score compared to the OVA group. NIC, Nicotine; OVA, ovalbumin.