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  Indian J Med Microbiol
 

Figure 3: The effects of co-administration of NIC and OVA on IL-4 and TGF-β production and TGF-Beta/IL-4 ratio. (A) Both doses of NIC (1 and 10 mg/kg) significantly reduced the IL-4 production compared to the OVA (###P ≤ 0.001) and control (***P ≤ 0.001) groups; (B) the co-administration of NIC and OVA did not increase the TGF-β production by splenocytes in RPMI 1640; and there was an insignificant difference between the groups; and (C) the TGF-β/IL-4 ratio in the mice from the OVA-NIC10 group was significantly higher than that of observed in the OVA (##P = 0.008), and control (**P = 0.010) groups. NIC, Nicotine; OVA, ovalbumin; TGF,.transforming growth factor; IL, interleukin.

Figure 3: The effects of co-administration of NIC and OVA on IL-4 and TGF-β production and TGF-Beta/IL-4 ratio. (A) Both doses of NIC (1 and 10 mg/kg) significantly reduced the IL-4 production compared to the OVA (<sup>###</sup><i>P</i> ≤ 0.001) and control (***<i>P</i> ≤ 0.001) groups; (B) the co-administration of NIC and OVA did not increase the TGF-β production by splenocytes in RPMI 1640; and there was an insignificant difference between the groups; and (C) the TGF-β/IL-4 ratio in the mice from the OVA-NIC10 group was significantly higher than that of observed in the OVA (<sup>##</sup><i>P</i> = 0.008), and control (**<i>P</i> = 0.010) groups. NIC, Nicotine; OVA, ovalbumin; TGF,.transforming growth factor; IL, interleukin.