|
 
 |
| REVIEW ARTICLE |
|
| Year : 2018 | Volume
: 13
| Issue : 4 | Page : 288-303 |
|
Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages
Parisa Ghasemiyeh1, Soliman Mohammadi-Samani2
1 Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran
2 Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran
| Date of Web Publication | 2-Jul-2018 |
Correspondence Address:
Soliman Mohammadi-Samani
Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz
I.R. Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1735-5362.235156
During the recent years, more attentions have been focused on lipid base drug delivery system to overcome some limitations of conventional formulations. Among these delivery systems solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are promising delivery systems due to the ease of manufacturing processes, scale up capability, biocompatibility, and also biodegradability of formulation constituents and many other advantages which could be related to specific route of administration or nature of the materials are to be loaded to these delivery systems. The aim of this article is to review the advantages and limitations of these delivery systems based on the route of administration and to emphasis the effectiveness of such formulations. Keywords: Drug delivery systems; Nanoparticles; Nanostructured lipid carriers (NLCs); Routes of administration; Solid lipid nanoparticles (SLNs)
How to cite this article:
Ghasemiyeh P, Mohammadi-Samani S. Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages. Res Pharma Sci 2018;13:288-303 |
How to cite this URL:
Ghasemiyeh P, Mohammadi-Samani S. Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages. Res Pharma Sci [serial online] 2018 [cited 2022 Jan 25];13:288-303. Available from: https://www.rpsjournal.net/text.asp?2018/13/4/288/235156 |
| 1. Introduction | |  |
Lipid nanoparticles as drug delivery systems were considered from the beginning of the 19th century by professor R. H. Müller from Germany and Professor M. Gascon from Italy [1],[2]. These nanoparticles are manufactured from solid or mixture of solid and liquid lipids and stabilized by emulsifiers.
Lipids used in these nanoparticles are biocompatible and completely tolerated by the body like triglycerides, fatty acids, steroids, and waxes. In addition, using combination of emulsifiers could stabilize the formulations more efficiently. Lipid nanoparticles have many advantages in comparison to other particulate systems such as the ease of large-scale production [3], biocompatible and biodegradable nature of the materials [4], low toxicity potential [5], possibility of controlled and modified drug release [6], drug solubility enhancement and the possibility of both hydrophilic and lipophilic drug incorporation. Lipid nanoparticles are different from micro-emulsions, which are clear thermodynamically stable dispersion of oil and water that are stabilized by surfactants and cosurfactants [7],[8]. The most important parameters in lipid nanoparticles characterization are particle size and size distribution, zeta potential, polymorphism, degree of crystallinity, drug loading, entrapment efficiency, and drug release. There are three different types of lipid nanoparticles: homogenous drug-lipid matrix, drug enriched core and drug enriched shell. Drug release from lipid nanoparticles is mostly dependent on the matrix type and location of drug in matrix formulation; for example in the third type, drug release from the nanocarriers shows more sustained release profile. The composition of lipid matrix, surfactant concentration and manufacturing parameters, such as temperature and stirring rate, can also affect drug release profiles. Probably the most important reasons of using lipid nanoparticles, as a suitable alternative of previous polymeric nanoparticles, are the ease of large-scale production and their low toxicity potential [1].
| 2. Types of Lipid Nanoparticles | | |
Solid lipid nanoparticles (SLNs) are the first generation of lipid-based nanocarriers that are formulated from lipids, which are solid in the body temperature and stabilized by emulsifiers [1]. SLNs have submicron (less than 1000 nm) sizes [9]. They have numerous advantages such as drug protection against harsh environmental situations, ease of large scale production using high pressure homogenization technique, biocompatibility, and biodegradability [10]. SLNs have also some disadvantages; because of their perfect crystalline structure, they have low drug loading efficiency [10] and the possibility of drug expulsion due to the crystallization process during the storage conditions. Another drawback is initial burst release [11] which usually occurs with these formulations. In SLNs drug molecules orients between the fatty acid chains or glycerides and during the storage periods and polymorphic changes in solid lipid structures there is a tendency to expulsion of previously dissolved drug in SLNs. [Figure 1] illustrates the actual place of drug orientation in SLNs and nanostructured lipid carriers (NLCs) schematically. | Figure 1: Schematic view of the solid lipid nanoparticle (SLN) and nanostructured lipid carriers (NLCs) showing the drug location within the lipid matrix.
Click here to view |
NLCs are second generation of lipid-based nanocarriers formed from mixture of solid and liquid lipids and have unstructured-matrix due to the different moieties of the constituents of NLCs [2]. NLCs were designed in order to overcome the SLNs limitations. NLCs have higher drug loading capacity because of imperfect crystal structure and could avoid drug expulsion by avoiding lipid crystallization during the manufacturing and storage periods. Due to the presence of liquid lipids in NLCs formulation expulsion of loaded drug after formulation and during the storage period is minimized. NLCs also can increase drug solubility in lipid matrix and they can show more controllable release profiles in comparison to SLNs [12]. Although NLCs are solid in nature even in body temperature but they have low melting point than SLNs and due to their unstructured nature and imperfection in their crystalline behaviors provide more space for drug dissolution and payload in liquid part of the NLCs. In this regard, loading capacity in NLCs are more than SLNs. Previous researches also confirm on less susceptibility of NLCs than SLNs to gelation during the preparation and storage period, which is another advantage of NLCs, NLCs can facilitate separation of nanoparticle from the rest of the medium and dosage form preparation for parenteral administration [2],[12].
| 3. Methods of Lipid Nano-Particles Preparation | | |
Lipid nanoparticles could be prepared by different methods such as hot and cold high pressure homogenization [13],[14], solvent emulsification/evaporation [15], microemulsion formation technique [16], and ultrasonic solvent emulsification [3]. Large-scale productions of lipid nanoparticles are mainly obtained by high pressure homogenization technique.
3.1. High pressure homogenization technique
3.1.1. Hot high pressure homogenization
In this method, lipid phase is heated up to 90 °C, then the hot lipid phase is dispersed in aqueous phase containing surfactants with same temperature. The pre-emulsion is homogenized at 90 °C under 3 cycles of high pressure homogenizer at 5 × 107 Pa. Finally, the obtained oil in water emulsion is cooled down to room temperature to solidify SLNs or NLCs [17].
3.1.2. Cold high pressure homogenization
In this method, the melted lipid phase is cooled to solidify and then ground to form lipid microparticles. Obtained lipid microparticles are dispersed in cool aqueous phase containing surfactants to form pre-suspension. Then the pre-suspension is homogenized under 5 cycles of high pressure homogenizer at room temperature and pressure of 1.5 × 108 Pa [18].
3.2. Solvent emulsification/evaporation technique
In this method, lipid phase is dissolved in an organic solvent such as acetone (organic phase). Then the organic phase is added to the aqueous phase (surfactant solution in water) under continuous stirring at 70-80 °C. The stirring will be continued until the organic phase is completely evaporated. Then obtained nanoemulsion is cooled (below 5 °C) to solidify lipid nanoparticles [15].
3.3. Microemulsion formation technique
In this method, lipids are melted at appropriate temperature and aqueous phase containing surfactants are heated up to same temperature. Then the hot aqueous phase will be added to the melted lipids under stirring at the same temperature. The hot oil in water microemulsion is dispersed in cold water at 1:50 ratio to solidify lipid nanoparticles [19].
3.4. Ultrasonic solvent emulsification technique
In this method, lipid phase is dissolved in an organic solvent such as dichloromethane and heated up to 50 °C. Then, aqueous phase containing surfactants and emulsifiers is heated up to the same temperature. After partial evaporation of dichloromethane, the aqueous phase is added to the organic phase under stirring at 50 °C. Obtained emulsion is sonicated for appropriate time and finally cooled in an ice bath to solidify lipid nanoparticles [3].
| 4. Lipid Nanoparticles Applications and Different Routes of Administration | | |
Numerous articles are reviewed and the results are categorized according to the routes of drug administration to six topics of topical, oral, parenteral, ocular, lung and brain delivery as shown in [Table 1].  | Table 1: Different loaded active compound and routes of administration of lipid nanoparticles.
Click here to view |
4.1. Topical route of administration
Skin related diseases are very common around the world. The major limitations for treatment of these diseases are low drug efficacy because of poor skin penetration or skin permeation of drugs from the most conventional formulations. Stratum corneum of epidermis is the major skin barrier and it should be bypassed through changing the penetration pathway from transcellular to paracellular or follicles. Lipid nanoparticles such as SLNs and NLCs have been developed to increase skin penetration or permeation. These particulate formulations are manufactured by mixing SLNs or NLCs with conventional formulations. They could be directly prepared in a one-step process which produce drug-loaded SLNs or NLCs. Lipid nanoparticles have so many advantages for topical drug delivery such as biocompatibility and biodegradability, controlled and extended drug release profile, close contact and strong skin adhesion, skin hydration and film formation in order to increase skin and dermal penetration [Table 2] [27],[29],[35],[36],[40]. | Table 2: Lipid nanoparticles advantages and disadvantages as topical drug delivery systems.
Click here to view |
4.2. Oral route
Oral drug administration is the most common route of drug delivery system because of the highest patient compliance. Low oral bioavailability due to limited drug solubility and/or high hepatic first pass effect are the most important limitations in oral drug delivery that should be overcome. Nanoparticle-based drug delivery systems were considered as suitable delivery system to increase oral bioavailability. Lipid nanoparticles such as SLNs and NLCs have the advantage of sustained drug release capability to maintain a constant plasma levels. In addition, nanoparticles with higher specific surface area and higher saturation solubility have more rapid dissolution rate that can accelerate the onset of drugs action. Other major barriers in oral drug delivery are p-glycoprotein efflux pumps and chemical or enzymatic degradation. Recent researches have shown that some specific lipids or surfactants, which are used in lipid nanoparticles, are capable of inhibiting p-glycoprotein efflux pumps. Drug-loaded lipid nanoparticles could reduce chemical or enzymatic degradation of the drugs which are embedded in a lipid matrix. Lipid nanoparticles could promote lymphatic transport and can bypass the liver and avoid hepatic first pass effect [50],[51],[52],[130],[131]. Lipid nanoparticles advantages and disadvantages for oral route are listed in [Table 3]. | Table 3: Lipid nanoparticles advantages and disadvantages as oral drug delivery systems.
Click here to view |
4.3. Ocular administration
Ocular drug delivery has many limitations and remains challenging because of specific physiological and anatomical features of the eyes. Eyes are a very complex and sophisticated organ and have several barriers that should be overcome in order to reach specific ocular tissue. Novel drug delivery systems such as lipid nanoparticles were considered to overcome these barriers and improve ocular tissue bioavailability. Topical application is the most common route of drug delivery to the anterior segment of the eyes. This route of administration has many advantages and is the choice for superficial ocular diseases. Major barriers in this pathway are corneal epithelium, blood ocular barrier, conjunctival blood flow, and tear drainage. Lipid nanoparticles which are used as ocular drug delivery systems are capable of passing blood ocular barrier, obtain sustained and controlled drug release, protect drugs from lacrimal enzymes and prolong drug deposition and residence time in eyes. Treatment of ocular diseases, which involve posterior segment of the eyes, is very difficult. There are different ways to target posterior segment of the eyes.
Topical route is not a suitable way to target intraocular tissues; other routes that are used for this purpose are transscleral delivery (subconjunctival and retrobulbar injection), intravitreal route, subretinal injection, etc. Most of these ways are invasive, so novel drug delivery systems such as lipid nanoparticles could be an appropriate alternative. Gene therapy for the purpose of retinal targeting in retinal diseases was also considered using non-viral vectors gene delivery including SLNs and NLCs [73],[74],[75],[76],[81]. A brief list of advantages and disadvantages of this route of administration are listed in [Table 4].  | Table 4: Lipid nanoparticles advantages and disadvantages as ocular drug delivery systems.
Click here to view |
4.4. Parenteral administration
Nanomedicine and nanotechnology play an important role in improving the parenteral drug delivery. Lipid nanoparticles advantages and disadvantages as parenteral drug delivery systems are listed in [Table 5]. The most important advantages of lipid nanoparticles for this purpose are ease of scale up production, biocompatible and biodegradable nature of the formulation constituents, controlled and modified drug release pattern, preventing drug degradation and maintaining more constant serum levels of drugs. Drug-loaded lipid nanoparticles may be injected intravenously, subcutaneously, intramuscularly, and directlyto target organs. Drug release from lipid nanoparticles may occur via erosion (such as enzymatic degradation) or via diffusion which could support a sustained drug release. Recent researches have confirmed the capability of lipid nanoparticles in peptide and protein incorporation. In this context, SLNs are not suitable carrier due to limited drug loading capacity but NLCs are appropriate alternative. In this method peptides and proteins can be protected from harsh environmental conditions [92],[93],[97],[100] . | Table 5: Lipid nanoparticles advantages and disadvantages as parenteral drug delivery systems.
Click here to view |
4.5. Pulmonary delivery
Pulmonary drug delivery is a relatively new approach, which has many advantages. It is a non-invasive route of drug delivery for both local and systemic administration. By this direct delivery system, drug dosage may be decreased and consequently drug adverse effects would be reduced. Direct drug inhalation can also accelerate onset of action. High drug accumulation in target site is another advantage of such administration route. Large surface area of pulmonary system and thin alveolar epithelium could guarantee high drug permeability. Lipid microparticles were used as delivery systems for lung targeting. These particulate systems showed good results such as drug bioavailability enhancement in comparison with conventional formulations. Lipid nanoparticles including SLNs and NLCs have been considered for pulmonary delivery. They have the advantage of sustaining drug release, biocompatibility and biodegradablity, lower toxicity and better stability in comparison with previously designed particulate systems. Pulmonary delivery of drug-loaded nanoparticles would result in high local concentration and can reduce systemic adverse effects. Also nanoparticles can achieve higher bioavailability for systemic delivery purposes. Lipid nanoparticles used in lung drug delivery, like other routes of administration, have the advantage of sustained drug delivery [103],[114],[117],[118]. Some of the most important advantages and limitations of this route of administration are listed in [Table 6]a. | Table 6: Lipid nanoparticles advantages and disadvantages as pulmonary drug delivery systems.
Click here to view |
4.6. Brain delivery
Drug delivery to the brain is one of the most important challenges in pharmaceutical sciences because of the presence of blood brain barrier (BBB). Nanoparticles with the advantage of small particle size and high drug encapsulation efficiency have been considered for specific targeting of brain tissues. Since nanoparticles can bypass reticuloendothelial system (RES), they are suitable as brain drug delivery systems. Two major obstacles in brain drug delivery are limited penetration of drugs across BBB and efflux of transported drugs from brain to blood circulation. Lipid nanoparticles such as SLNs and NLCs are one of the colloidal drug delivery systems that have been utilized to overcome these barriers. Lipid nanoparticles advantages and limitations as brain drug delivery systems are listed in [Table 7]. Lipid nanoparticles have the advantage of increasing drug retention time in blood of brain capillaries and inducing a drug gradient from blood to brain tissues, opening tight junctions to facilitate passage from BBB and transcytosis of drug-loaded lipid nanoparticles through the endothelium layer. Lipid nanoparticles are suitable for incorporating both lipophilic and hydrophilic drugs which could be administered via different routes [120],[121],[122],[123],[124],[125],[126],[127],[128],[129]. Previous researches emphasized on significant effect of surfactant suitability for brain drug delivery. Appropriate surfactants could be chosen according to their HLB and packing parameter. For site-specific brain drug delivery, polysorbates especially polysorbate 80, has shown best results. In addition, results showed that positively charged lipid nanoparticles induce better drug accumulation in the brain [123]. | Table 7: Lipid nanoparticles advantages and disadvantages as brain drug delivery systems.
Click here to view |
| 5. Commercially Available Products from Lipid Nano-Particles in Market | | |
Today, most of the commercially available products from lipid nanoparticles are cosmetic products such as Cutanova Cream Nano Repair Q10, Intensive Serum Nano Repair Q10, Cutanova Cream Nano Vital Q10, SURMER Crème Legère Nano-Protection, SURMER Crème Riche Nano-Restructurante, SURMER Elixir du Beauté Nano-Vitalisant, SURMER Masque Crème Nano-Hydratant, NanoLipid Restore CLR, NanoLipid Q10 CLR, NanoLipid Basic CLR, NanoLipid Repair CLR, IOPE SuperVital cream, serum, eye cream, extra moist softener and extra moist emulsion, NLC Deep Effect Eye Serum, NLC Deep Effect Repair Cream, NLC Deep Effect Reconstruction Cream, NLC Deep Effect Reconstruction Serum, Regenerations Creme Intensiv Scholl, Swiss Cellular White Illuminating Eye Essence, Swiss Cellular White Intensive Ampoules, SURMER Creme Contour Des Yeux Nano-Remodelante, Olivenöl Anti Falten Pflegekonzentrat, Olivenöl Augenpflegebalsam [18].
| 6. Conclusion | | |
lipid nanoparticles are novel drug deivery systems which have many advantages over other colloidal and polymeric nanocarriers. The most important advantages of lipid carriers are their biocompatibility, biodegradability, ease of scalability, and controlled and modified release patterns. Among these two types of lipid nanoparticles (SLN and NLC), NLCs as a second generation of lipid nanoparticles, has shown better results for the purpose of targeted drug delivery and nowadays are more considered for different routes of administration. Lipid nanoparticles are suitable carriers for both hydrophilic and lipophilic drugs. They can be administered by different routes such as topical, oral, parenteral, ocular, pulmonary, brain drug delivery. These nanoparticles for each routes of administration have its own advantages and also limitations that should be considered. Lipid nanoaprticles are promising drug delivery systems for delivery of various pharmaceutically important active ingredients from small molecule to protein and gene in early future.
| Acknowledgement | | |
The content of this paper is taken from the Pharm.D thesis (Grant No. 95010511769) submitted by Parisa Ghasemiyeh and was financially supported by the vice chancellery research of Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
| References | | |
| 1. | MuÈller RH, Mader K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery–a review of the state of the art. Eur J Pharm Biopharm. 2000;50(1):161-177.  |
| 2. | Beloqui A, Solinis MA, Rodriguez-Gascon A, Almeida AJ, Preat V. Nanostructured lipid carriers: Promising drug delivery systems for future clinics. Nanomedicine. 2016;12(1):143-161. |
| 3. | Luo Y, Chen D, Ren L, Zhao X, Qin J. Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability. J Control Release. 2006;114(1):53-59. |
| 4. | Silva A, González-Mira E, García ML, Egea MA, Fonseca J, Silva R, et al. Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): high pressure homogenization versus ultrasound. Colloids Surf B Biointerfaces. 2011;86(1):158-165. |
| 5. | Schwarz C, Mehnert W, Lucks JS, Müller RH. Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization. J. Control. Release. 1994;30(1):83-96. |
| 6. | zur Mühlen A, Schwarz C, Mehnert W. Solid lipid nanoparticles (SLN) for controlled drug delivery–drug release and release mechanism. Eur J Pharm Biopharm. 1998;45(2):149-155. |
| 7. | Wang X, Chen H, Luo Z, Fu X. Preparation of starch nanoparticles in water in oil microemulsion system and their drug delivery properties. Carbohydr Polym. 2016;138:192-200. |
| 8. | Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res. 1995;12(11):1561-1572. |
| 9. | Doktorovova S, Kovacevic AB, Garcia ML, Souto EB. Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: Current evidence from in vitro and in vivo evaluation. Eur J Pharm Biopharm. 2016;108:235-252 |
| 10. | Yoon G, Park JW, Yoon IS. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs): recent advances in drug delivery. J Pharm Investig. 2013;43(5):353-362. |
| 11. | Makwana V, Jain R, Patel K, Nivsarkar M, Joshi A. Solid lipid nanoparticles (SLN) of Efavirenz as lymph targeting drug delivery system: Elucidation of mechanism of uptake using chylomicron flow blocking approach. Int J Pharm. 2015;495(1):439-446. |
| 12. | Shidhaye SS, Vaidya R, Sutar S, Patwardhan A, Kadam VJ. Solid lipid nanoparticles and nanostructured lipid carriers-innovative generations of solid lipid carriers. Curr Drug Deliv. 2008;5(4):324-231. |
| 13. | Kasongo KW, Muller RH, Walker RB. The use of hot and cold high pressure homogenization to enhance the loading capacity and encapsulation efficiency of nanostructured lipid carriers for the hydrophilic antiretroviral drug, didanosine for potential administration to paediatric patients. Pharm Dev Technol. 2012;17(3):353-362. |
| 14. | Souto EB, Müller RH. Investigation of the factors influencing the incorporation of clotrimazole in SLN and NLC prepared by hot high-pressure homogenization. J Microencapsul. 2006;23(4):377-388. |
| 15. | Chen DB, Yang TZ, Lu WL, Zhang Q. In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel. Chem Pharm Bull (Tokyo). 2001;49(11):1444-1447. |
| 16. | Mojahedian MM, Daneshamouz S, Samani SM, Zargaran A. A novel method to produce solid lipid nanoparticles using n-butanol as an additional co-surfactant according to the o/w microemulsion quenching technique. Chem Phys Lipids. 2013;174:32-38. |
| 17. | Souto EB, Wissing SA, Barbosa CM, Müller RH. Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery. Int J Pharm. 2004;278(1):71-77. |
| 18. | Pardeike J, Hommoss A, Muller RH. Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int J Pharm. 2009;366(1-2):170-184. |
| 19. | Shah RM, Malherbe F, Eldridge D, Palombo EA, Harding IH. Physicochemical characterization of solid lipid nanoparticles (SLNs) prepared by a novel microemulsion technique. J. Colloid Interface Sci. 2014;428:286-294. |
| 20. | Gainza G, Pastor M, Aguirre JJ, Villullas S, Pedraz JL, Hernandez RM, et al. A novel strategy for the treatment of chronic wounds based on the topical administration of rhEGF-loaded lipid nanoparticles: In vitro bioactivity and in vivo effectiveness in healing-impaired db/db mice. J Control Release. 2014;185:51-61. |
| 21. | Vitorino C, Almeida A, Sousa J, Lamarche I, Gobin P, Marchand S, et al. Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: in vitro vs. in vivo studies. Eur J Pharm Biopharm. 2014;86(2):133-144. |
| 22. | Gainza G, Bonafonte DC, Moreno B, Aguirre JJ, Gutierrez FB, Villullas S, et al. The topical administration of rhEGF-loaded nanostructured lipid carriers (rhEGF-NLC) improves healing in a porcine full-thickness excisional wound model. J Control Release. 2015;197:41-47. |
| 23. | Nnamani PO, Hansen S, Windbergs M, Lehr CM. Development of artemether-loaded nanostructured lipid carrier (NLC) formulation for topical application. Int J Pharm. 2014;477(1-2):208-217. |
| 24. | Park JH, Ban SJ, Ahmed T, Choi HS, Yoon HE, Yoon JH, et al. Development of DH-I-180-3 loaded lipid nanoparticle for photodynamic therapy. Int J Pharm. 2015;491(1-2):393-401. |
| 25. | Ferreira M, Silva E, Barreiros L, Segundo MA, Lima CSA, Reis S. Methotrexate loaded lipid nanoparticles for topical management of skin-related diseases: Design, characterization and skin permeation potential. Int J Pharm. 2016;512(1):14-21. |
| 26. | Jain AK, Jain A, Garg NK, Agarwal A, Jain A, Jain SA, et al. Adapalene loaded solid lipid nanoparticles gel: an effective approach for acne treatment. Colloids Surf B Biointerfaces. 2014;121:222-229. |
| 27. | Butani D, Yewale C, Misra A. Topical Amphotericin B solid lipid nanoparticles: Design and development. Colloids Surf B Biointerfaces. 2016;139:17-24. |
| 28. | Lohan SB, Bauersachs S, Ahlberg S, Baisaeng N, Keck CM, Muller RH, et al. Ultra-small lipid nanoparticles promote the penetration of coenzyme Q10 in skin cells and counteract oxidative stress. Eur J Pharm Biopharm. 2015;89:201-207. |
| 29. | Chen J, Wei N, Lopez-Garcia M, Ambrose D, Lee J, Annelin C, et al. Development and evaluation of resveratrol, Vitamin E, and epigallocatechin gallate loaded lipid nanoparticles for skin care applications. Eur J Pharm Biopharm. 2017;117:286-291. |
| 30. | Jenning V, Gysler A, Schäfer-Korting M, Gohla SH. Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. Eur J Pharm Biopharm. 2000;49(3):211-218. |
| 31. | Stecova J, Mehnert W, Blaschke T, Kleuser B, Sivaramakrishnan R, Zouboulis CC, et al. Cyproterone acetate loading to lipid nanoparticles for topical acne treatment: particle characterisation and skin uptake. Pharm Res. 2007;24(5):991-1000. |
| 32. | Üner M, Karaman EF, Aydoğmuş Z. Solid lipid nanoparticles and nanostructured lipid carriers of loratadine for topical application: physicochemical stability and drug penetration through rat skin. Trop J Pharm Res. 2014;13(5):653-660. |
| 33. | Bikkad ML, Nathani AH, Mandlik SK, Shrotriya SN, Ranpise NS. Halobetasol propionate-loaded solid lipid nanoparticles (SLN) for skin targeting by topical delivery. J Liposome Res. 2014;24(2):113-123. |
| 34. | Charoenputtakhun P, Opanasopit P, Rojanarata T, Ngawhirunpat T. All-trans retinoic acid-loaded lipid nanoparticles as a transdermal drug delivery carrier. Pharm Dev Technol. 2014;19(2):164-172. |
| 35. | Desmet E, Van Gele M, Lambert J. Topically applied lipid- and surfactant-based nanoparticles in the treatment of skin disorders. Expert Opin Drug Deliv. 2017;14(1):109-122. |
| 36. | Lauterbach A, Muller-Goymann CC. Applications and limitations of lipid nanoparticles in dermal and transdermal drug delivery via the follicular route. Eur J Pharm Biopharm. 2015;97(Pt A):152-163. |
| 37. | Müller RH, Staufenbiel S, Keck CM. Lipid nanoparticles (SLN, NLC) for innovative consumer care and household products. H and PC Today. 2014;9(2):18-25. |
| 38. | Gonullu U, Uner M, Yener G, Karaman EF, Aydogmus Z. Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery. Acta Pharm. 2015;65(1):1-13. |
| 39. | Hamishehkar H, Shokri J, Fallahi S, Jahangiri A, Ghanbarzadeh S, Kouhsoltani M. Histopathological evaluation of caffeine-loaded solid lipid nanoparticles in efficient treatment of cellulite. Drug Dev Ind Pharm. 2015;41(10):1640-1646. |
| 40. | Marto J, Sangalli C, Capra P, Perugini P, Ascenso A, Goncalves L, et al. Development and characterization of new and scalable topical formulations containing N-acetyl-d-glucosamine-loaded solid lipid nanoparticles. Drug Dev Ind Pharm. 2017;43(11):1792-1800. |
| 41. | Puglia C, Bonina F. Lipid nanoparticles as novel delivery systems for cosmetics and dermal pharmaceuticals. Expert Opin Drug Deliv. 2012;9(4):429-241. |
| 42. | Puglia C, Lauro MR, Offerta A, Crasci L, Micicche L, Panico AM, et al. Nanostructured lipid carriers (NLC) as vehicles for topical administration of sesamol: in vitro percutaneous absorption study and evaluation of antioxidant activity. Planta Med. 2017;83(5):398-404. |
| 43. | Puglia C, Offerta A, Tirendi GG, Tarico MS, Curreri S, Bonina F, et al. Design of solid lipid nanoparticles for caffeine topical administration. Drug Deliv. 2016;23(1):36-40. |
| 44. | Teeranachaideekul V, Chantaburanan T, Junyaprasert VB. Influence of state and crystallinity of lipid matrix on physicochemical properties and permeation of capsaicin-loaded lipid nanoparticles for topical delivery. J Drug Deliv Sci Technol. 2017;39:300-307. |
| 45. | Muller RH, Runge S, Ravelli V, Mehnert W, Thunemann AF, Souto EB. Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN) versus drug nanocrystals. Int J Pharm. 2006;317(1):82-89. |
| 46. | Sangsen Y, Wiwattanawongsa K, Likhitwitayawuid K, Sritularak B, Wiwattanapatapee R. Modification of oral absorption of oxyresveratrol using lipid based nanoparticles. Colloids Surf B Biointerfaces. 2015;131:182-190. |
| 47. | Zhuang CY, Li N, Wang M, Zhang XN, Pan WS, Peng JJ, et al. Preparation and characterization of vinpocetine loaded nanostructured lipid carriers (NLC) for improved oral bioavailability. Int J Pharm. 2010;394(1-2):179-185. |
| 48. | Shangguan M, Qi J, Lu Y, Wu W. Comparison of the oral bioavailability of silymarin-loaded lipid nanoparticles with their artificial lipolysate counterparts: implications on the contribution of integral structure. Int J Pharm. 2015;489(1-2):195-202. |
| 49. | Zhang Y, Li Z, Zhang K, Yang G, Wang Z, Zhao J, et al. Ethyl oleate-containing nanostructured lipid carriers improve oral bioavailability of trans -ferulic acid ascompared with conventional solid lipid nanoparticles. Int J Pharm. 2016;511(1):57-64. |
| 50. | Garg A, Bhalala K, Tomar DS, Wahajuddin. In-situ single pass intestinal permeability and pharmacokinetic study of developed Lumefantrine loaded solid lipid nanoparticles. Int J Pharm. 2017;516(1-2):120-30. |
| 51. | Cirri M, Mennini N, Maestrelli F, Mura P, Ghelardini C, Mannelli DCL. Development and in vivo evaluation of an innovative “Hydrochlorothiazide-in Cyclodextrins-in Solid Lipid Nanoparticles” formulation with sustained release and enhanced oral bioavailability for potential hypertension treatment in pediatrics. Int J Pharm. 2017;521(1-2):73-83. |
| 52. | Luan J, Zheng F, Yang X, Yu A, Zhai G. Nanostructured lipid carriers for oral delivery of baicalin: In vitro and in vivo evaluation. Colloids Surf. A. 2015;466:154-159. |
| 53. | Mendes AI, Silva AC, Catita JA, Cerqueira F, Gabriel C, Lopes CM. Miconazole-loaded nanostructured lipid carriers (NLC) for local delivery to the oral mucosa: improving antifungal activity. Colloids Surf B Biointerfaces. 2013;111:755-763. |
| 54. | Ranpise NS, Korabu SS, Ghodake VN. Second generation lipid nanoparticles (NLC) as an oral drug carrier for delivery of lercanidipine hydrochloride. Colloids Surf B Biointerfaces. 2014;116:81-87. |
| 55. | Ravi PR, Aditya N, Kathuria H, Malekar S, Vats R. Lipid nanoparticles for oral delivery of raloxifene: optimization, stability, in vivo evaluation and uptake mechanism. Eur J Pharm Biopharm. 2014;87(1):114-124. |
| 56. | Patil-Gadhe A, Pokharkar V. Montelukast-loaded nanostructured lipid carriers: part I oral bioavailability improvement. Eur J Pharm Biopharm. 2014;88(1):160-168. |
| 57. | Goncalves LMd, Maestrelli F, Mannelli DCL, Ghelardini C, Almeida AJ, Mura P. Development of solid lipid nanoparticles as carriers for improving oral bioavailability of glibenclamide. Eur J Pharm Biopharm. 2016;102:41-50. |
| 58. | Pandita D, Kumar S, Poonia N, Lather V. Solid lipid nanoparticles enhance oral bioavailability of resveratrol, a natural polyphenol. Food Res Int. 2014;62:1165-1174. |
| 59. | Desai PP, Date AA, Patravale VB. Overcoming poor oral bioavailability using nanoparticle formulations - opportunities and limitations. Drug Discov Today Technol. 2012;9(2):e71-e174. |
| 60. | Beloqui A, Solinis MA, Delgado A, Evora C, Isla A, Rodriguez-Gascon A. Fate of nanostructured lipid carriers (NLCs) following the oral route: design, pharmacokinetics and biodistribution. J Microencapsul. 2014;31(1):1-8. |
| 61. | Shah MK. Solid lipid nanoparticles (SLN) for oral drug delivery: an overview. J Nanomed Nanosci. 2017. |
| 62. | Muchow M, Maincent P, Müller RH. Lipid nanoparticles with a solid matrix (SLN, NLC, LDC) for oral drug delivery. Drug Dev Ind Pharm. 2008;34(12):1394-1405. |
| 63. | Nunes S, Madureira AR, Campos D, Sarmento B, Gomes AM, Pintado M, et al. Solid lipid nanoparticles as oral delivery systems of phenolic compounds: Overcoming pharmacokinetic limitations for nutraceutical applications. Crit Rev Food Sci Nutr. 2017;57(9):1863-1873. |
| 64. | Rao S, Prestidge CA. Polymer-lipid hybrid systems: merging the benefits of polymeric and lipid-based nanocarriers to improve oral drug delivery. Expert Opin Drug Deliv. 2016;13(5):691-707. |
| 65. | Leonardi A, Bucolo C, Romano GL, Platania CB, Drago F, Puglisi G, et al. Influence of different surfactants on the technological properties and in vivo ocular tolerability of lipid nanoparticles. Int J Pharm. 2014;470(1-2):133-140. |
| 66. | Attama AA, Reichl S, Müller-Goymann CC. Diclofenac sodium delivery to the eye: in vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct. International journal of pharmaceutics. 2008;355(1-2):307-313. |
| 67. | Li X, Nie Sf, Kong J, Li N, Ju CY, Pan WS. A controlled-release ocular delivery system for ibuprofen based on nanostructured lipid carriers. Int J Pharm. 2008;363(1-2):177-182. |
| 68. | Luo Q, Zhao J, Zhang X, Pan W. Nanostructured lipid carrier (NLC) coated with Chitosan Oligosaccharides and its potential use in ocular drug delivery system. Int J Pharm. 2011;403(1-2):185-191. |
| 69. | Araújo J, Gonzalez E, Egea MA, Garcia ML, Souto EB. Nanomedicines for ocular NSAIDs: safety on drug delivery. Nanomedicine. 2009;5(4):394-401. |
| 70. | Araújo J, Gonzalez-Mira E, Egea MA, Garcia ML, Souto EB. Optimization and physicochemical characterization of a triamcinolone acetonide-loaded NLC for ocular antiangiogenic applications. Int J Pharm. 2010;393(1-2):167-75. |
| 71. | Fangueiro JF, Andreani T, Egea MA, Garcia ML, Souto SB, Silva AM, et al. Design of cationic lipid nanoparticles for ocular delivery: development, characterization and cytotoxicity. Int J Pharm. 2014;461(1-2):64-73. |
| 72. | Balguri SP, Adelli GR, Janga KY, Bhagav P, Majumdar S. Ocular disposition of ciprofloxacin from topical, PEGylated nanostructured lipid carriers: Effect of molecular weight and density of poly (ethylene) glycol. Int J Pharm.. 2017;529(1-2):32-43. |
| 73. | Balguri SP, Adelli GR, Majumdar S. Topical ophthalmic lipid nanoparticle formulations (SLN, NLC) of indomethacin for delivery to the posterior segment ocular tissues. Eur J Pharm Biopharm. 2016;109:224-235. |
| 74. | Chetoni P, Burgalassi S, Monti D, Tampucci S, Tullio V, Cuffini AM, et al. Solid lipid nanoparticles as promising tool for intraocular tobramycin delivery: Pharmacokinetic studies on rabbits. Eur J Pharm Biopharm. 2016;109:214-223. |
| 75. | Sánchez-López E, Espina M, Doktorovova S, Souto EB, García ML. Lipid nanoparticles (SLN, NLC): Overcoming the anatomical and physiological barriers of the eye - Part I - Barriers and determining factors in ocular delivery. Eur J Pharm Biopharm. 2017;110:70-75. |
| 76. | Sánchez-López E, Espina M, Doktorovova S, Souto EB, García ML. Lipid nanoparticles (SLN, NLC): Overcoming the anatomical and physiological barriers of the eye - Part II - Ocular drug-loaded lipid nanoparticles. Eur J Pharm Biopharm. 2017;110:58-69. |
| 77. | Liu D, Li J, Cheng B, Wu Q, Pan H. Ex Vivo and in Vivo evaluation of the effect of coating a coumarin-6-labeled nanostructured lipid carrier with chitosan-N-acetylcysteine on rabbit ocular distribution. Mol Pharm. 2017;14(8):2639-2648. |
| 78. | Almeida H, Amaral MH, Lobão P, Silva AC, Loboa JM. Applications of polymeric and lipid nanoparticles in ophthalmic pharmaceutical formulations: present and future considerations. J Pharm Pharm Sci. 2014;17(3):278-293. |
| 79. | Andrade LM, Rocha KA, De Sá FA, Marreto RN, Lima EM, Gratieri T, et al. Voriconazole-loaded nanostructured lipid carriers for ocular drug delivery. Cornea. 2016;35(6):866-871. |
| 80. | Basaran E, Demirel M, Sirmagül B, Yazan Y. Cyclosporine-A incorporated cationic solid lipid nanoparticles for ocular delivery. J Microencapsul. 2010;27(1):37-47. |
| 81. | Battaglia L, Serpe L, Foglietta F, Muntoni E, Gallarate M, Rodriguez DPA, et al. Application of lipid nanoparticles to ocular drug delivery. Expert Opin Drug Deliv. 2016;13(12):1743-1757. |
| 82. | Seyfoddin A, Shaw J, Al-Kassas R. Solid lipid nanoparticles for ocular drug delivery. Drug Deliv. 2010;17(7):467-489. |
| 83. | Souto EB, Doktorovova S, Gonzalez-Mira E, Egea MA, Garcia ML. Feasibility of lipid nanoparticles for ocular delivery of anti-inflammatory drugs. Curr Eye Res. 2010;35(7):537-552. |
| 84. | Wissing SA, Kayser O, Muller RH. Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev. 2004;56(9):1257-1272. |
| 85. | Almeida AJ, Souto E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv Drug Deliv Rev. 2007;59(6):478-490. |
| 86. | Wong HL, Bendayan R, Rauth AM, Li Y, Wu XY. Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv Drug Deliv Rev. 2007;59(6):491-504. |
| 87. | Hommoss G, Pyo SM, Müller RH. Mucoadhesive tetrahydrocannabinol-loaded NLC - Formulation optimization and long-term physicochemical stability. Eur J Pharm Biopharm. 2017;117:408-417. |
| 88. | Muller RH, Keck CM. Challenges and solutions for the delivery of biotech drugs--a review of drug nanocrystal technology and lipid nanoparticles. J Biotechnol. 2004;113(1-3):151-170. |
| 89. | Kim JK, Park JS, Kim CK. Development of a binary lipid nanoparticles formulation of itraconazole for parenteral administration and controlled release. Int J Pharm. 2010;383(1-2):209-215. |
| 90. | Bhise K, Kashaw SK, Sau S, Iyer AK. Nanostructured lipid carriers employing polyphenols as promising anticancer agents: Quality by design (QbD) approach. Int J Pharm. 2017;526(1-2):506-515. |
| 91. | Jia L, Zhang D, Li Z, Duan C, Wang Y, Feng F, et al. Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies. Colloids Surf B Biointerfaces. 2010;80(2):213-218. |
| 92. | Liu D, Liu Z, Wang L, Zhang C, Zhang N. Nanostructured lipid carriers as novel carrier for parenteral delivery of docetaxel. Colloids Surf B Biointerfaces. 2011;85(2):262-269. |
| 93. | Luan J, Zhang D, Hao L, Qi L, Liu X, Guo H, et al. Preparation, characterization and pharmacokinetics of Amoitone B-loaded long circulating nanostructured lipid carriers. Colloids and surfaces B, Biointerfaces. 2014;114:255-60. |
| 94. | Joshi MD, Müller RH. Lipid nanoparticles for parenteral delivery of actives. Eur J Pharm Biopharm. 2009;71(2):161-172. |
| 95. | Ajorlou E, Khosroushahi AY. Trends on polymer- and lipid-based nanostructures for parenteral drug delivery to tumors. Cancer Chemother Pharmacol. 2017;79(2):251-265. |
| 96. | Mussi SV, Sawant R, Perche F, Oliveira MC, Azevedo RB, Ferreira LA, et al. Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells. Pharm Res. 2014;31(8):1882-1892. |
| 97. | Chinsriwongkul A, Chareanputtakhun P, Ngawhirunpat T, Rojanarata T, Sila-on W, Ruktanonchai U, et al. Nanostructured lipid carriers (NLC) for parenteral delivery of an anticancer drug. AAPS PharmSciTech. 2012;13(1):150-158. |
| 98. | Wu M, Fan Y, Lv S, Xiao B, Ye M, Zhu X. Vincristine and temozolomide combined chemotherapy for the treatment of glioma: a comparison of solid lipid nanoparticles and nanostructured lipid carriers for dual drugs delivery. Drug Deliv. 2016;23(8):2720-2725. |
| 99. | Martins S, Sarmento B, Ferreira DC, Souto EB. Lipid-based colloidal carriers for peptide and protein delivery-liposomes versus lipid nanoparticles. Int J Nanomedicine. 2007;2(4):595-607. |
| 100. | Qureshi OS, Kim HS, Zeb A, Choi JS, Kim HS, Kwon JE, et al. Sustained release docetaxel-incorporated lipid nanoparticles with improved pharmacokinetics for oral and parenteral administration. J Microencapsul. 2017;34(3):250-261. |
| 101. | Zeb A, Qureshi OS, Kim HS, Kim MS, Kang JH, Park JS, et al. High payload itraconazole-incorporated lipid nanoparticles with modulated release property for oral and parenteral administration. J Pharm Pharmacol. 2017;69(8):955-966. |
| 102. | Ahmadnia S, Moazeni M, Mohammadi-Samani S, Oryan A. In vivo evaluation of the efficacy of albendazole sulfoxide and albendazole sulfoxide loaded solid lipid nanoparticles against hydatid cyst. Exp Parasitol. 2013;135(2):314-319. |
| 103. | Cipolla D, Shekunov B, Blanchard J, Hickey A. Lipid-based carriers for pulmonary products: preclinical development and case studies in humans. Adv Drug Deliv Rev. 2014;75:53-80. |
| 104. | Taratula O, Kuzmov A, Shah M, Garbuzenko OB, Minko T. Nanostructured lipid carriers as multifunctional nanomedicine platform for pulmonary co-delivery of anticancer drugs and siRNA. J Control Release. 2013;171(3):349-357. |
| 105. | Pardeike J, Weber S, Haber T, Wagner J, Zarfl HP, Plank H, et al. Development of an itraconazole-loaded nanostructured lipid carrier (NLC) formulation for pulmonary application. Int J Pharm. 2011;419(1-2):329-338. |
| 106. | Patil-Gadhe A, Kyadarkunte A, Patole M, Pokharkar V. Montelukast-loaded nanostructured lipid carriers: part II pulmonary drug delivery and in vitro-in vivo aerosol performance. Eur J Pharm Biopharm. 2014;88(1):169-177. |
| 107. | Patil-Gadhe A, Pokharkar V. Pulmonary targeting potential of rosuvastatin loaded nanostructured lipid carrier: Optimization by factorial design. Int J Pharm. 2016;501(1-2):199-210. |
| 108. | Hidalgo A, Cruz A, Perez-Gil J. Barrier or carrier? Pulmonary surfactant and drug delivery. Eur J Pharm Biopharm. 2015;95(Pt A):117-127. |
| 109. | Patlolla RR, Chougule M, Patel AR, Jackson T, Tata PN, Singh M. Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers. J Control Release. 2010;144(2):233-241. |
| 110. | Nafee N, Husari A, Maurer CK, Lu C, de Rossi C, Steinbach A, et al. Antibiotic-free nanotherapeutics: ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors. J Control Release. 2014;192:131-140. |
| 111. | Paranjpe M, Finke JH, Richter C, Gothsch T, Kwade A, Buttgenbach S, et al. Physicochemical characterization of sildenafil-loaded solid lipid nanoparticle dispersions (SLN) for pulmonary application. Int J Pharm. 2014;476(1-2):41-49. |
| 112. | Moreno-Sastre M, Pastor M, Esquisabel A, Sans E, Vinas M, Fleischer A, et al. Pulmonary delivery of tobramycin-loaded nanostructured lipid carriers for Pseudomonas aeruginosa infections associated with cystic fibrosis. Int J Pharm. 2016;498(1-2):263-273. |
| 113. | Zhao Y, Chang YX, Hu X, Liu CY, Quan LH, Liao YH. Solid lipid nanoparticles for sustained pulmonary delivery of Yuxingcao essential oil: Preparation, characterization and in vivo evaluation. Int J Pharm. 2017;516(1-2):364-371. |
| 114. | Makled S, Nafee N, Boraie N. Nebulized solid lipid nanoparticles for the potential treatment of pulmonary hypertension via targeted delivery of phosphodiesterase-5-inhibitor. Int J Pharm. 2017;517(1-2):312-321. |
| 115. | Islan GA, Tornello PC, Abraham GA, Duran N, Castro GR. Smart lipid nanoparticles containing levofloxacin and DNase for lung delivery. Design and characterization. Colloids Surf B Biointerfaces. 2016;143:168-176. |
| 116. | Weber S, Zimmer A, Pardeike J. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for pulmonary application: a review of the state of the art. Eur J Pharm Biopharm. 2014;86(1):7-22. |
| 117. | Pardeike J, Weber S, Zarfl HP, Pagitz M, Zimmer A. Itraconazole-loaded nanostructured lipid carriers (NLC) for pulmonary treatment of aspergillosis in falcons. Eur J Pharm Biopharm. 2016;108:269-276. |
| 118. | Kaur P, Garg T, Rath G, Murthy RS, Goyal AK. Development, optimization and evaluation of surfactant-based pulmonary nanolipid carrier system of paclitaxel for the management of drug resistance lung cancer using Box-Behnken design. Drug Deliv. 2016;23(6):1912-125. |
| 119. | Paranjpe M, Muller-Goymann CC. Nanoparticle-mediated pulmonary drug delivery: a review. Int J Mol Sci. 2014;15(4):5852-5873. |
| 120. | Kaur IP, Bhandari R, Bhandari S, Kakkar V. Potential of solid lipid nanoparticles in brain targeting. J Control Release. 2008;127(2):97-109. |
| 121. | Dal Magro R, Ornaghi F, Cambianica I, Beretta S, Re F, Musicanti C, et al. ApoE-modified solid lipid nanoparticles: A feasible strategy to cross the blood-brain barrier. J Control Release. 2017;249:103-110. |
| 122. | Blasi P, Giovagnoli S, Schoubben A, Puglia C, Bonina F, Rossi C, et al. Lipid nanoparticles for brain targeting I. Formulation optimization. Int J Pharm. 2011;419(1-2):287-295. |
| 123. | Blasi P, Giovagnoli S, Schoubben A, Ricci M, Rossi C. Solid lipid nanoparticles for targeted brain drug delivery. Adv Drug Deliv Rev. 2007;59(6):454-477. |
| 124. | Blasi P, Schoubben A, Romano GV, Giovagnoli S, Michele DA, Ricci M. Lipid nanoparticles for brain targeting II. Technological characterization. Colloids Surf B Biointerfaces. 2013;110:130-137. |
| 125. | Blasi P, Schoubben A, Traina G, Manfroni G, Barberini L, Alberti PF, et al. Lipid nanoparticles for brain targeting III. Long-term stability and in vivo toxicity. Int J Pharm. 2013;454(1):316-323. |
| 126. | Gastaldi L, Battaglia L, Peira E, Chirio D, Muntoni E, Solazzi I, et al. Solid lipid nanoparticles as vehicles of drugs to the brain: current state of the art. Eur J Pharm Biopharm. 2014;87(3):433-444. |
| 127. | Montenegro L, Campisi A, Sarpietro MG, Carbone C, Acquaviva R, Raciti G, et al. In vitro evaluation of idebenone-loaded solid lipid nanoparticles for drug delivery to the brain. Drug Dev Ind Pharm. 2011;37(6):737-746. |
| 128. | Patel S, Chavhan S, Soni H, Babbar AK, Mathur R, Mishra AK, et al. Brain targeting of risperidone-loaded solid lipid nanoparticles by intranasal route. J Drug Target 2011;19(6):468-474. |
| 129. | Tosi G, Musumeci T, Ruozi B, Carbone C, Belletti D, Pignatello R, et al. The “fate” of polymeric and lipid nanoparticles for brain delivery and targeting: Strategies and mechanism of blood-brain barrier crossing and trafficking into the central nervous system. J Drug Deliv Sci Technol. 2016;32:66-76. |
| 130. | Severino P, Andreani T, Macedo AS, Fangueiro JF, Santana MH, Silva AM, et al. Current state-of-art and new trends on lipid nanoparticles (SLN and NLC) for oral drug delivery. J Drug Deliv. 2012;2012:1-10. |
| 131. | Tran TH, Ramasamy T, Truong DH, Choi HG, Yong CS, Kim JO. Preparation and characterization of fenofibrate-loaded nanostructured lipid carriers for oral bioavailability enhancement. AAPS PharmSciTech. 2014;15(6):1509-1515. |
| 132. | Khan S, Baboota S, Ali J, Khan S, Narang RS, Narang JK. Nanostructured lipid carriers: An emerging platform for improving oral bioavailability of lipophilic drugs. Int J Pharm Investig. 2015;5(4):182-191. |
| 133. | Hosseini M, Haji-Fatahaliha M, Jadidi-Niaragh F, Majidi J, Yousefi M. The use of nanoparticles as a promising therapeutic approach in cancer immunotherapy. Artif Cells Nanomed Biotechnol. 2016;44(4):1051-1061. |
| 134. | Attama AA. SLN, NLC, LDC: state of the art in drug and active delivery. Recent Pat Drug Deliv Formul. 2011;5(3):178-187. |
| 135. | Selvamuthukumar S, Velmurugan R. Nanostructured lipid carriers: a potential drug carrier for cancer chemotherapy. Lipids Health Dis. 2012;11(1):159-166. |
| 136. | Prasad D, Chauhan H. Nanotoxicity of Polymeric and Solid Lipid Nanoparticles. In:. Sutariya VB, Pathak Y, editors. Biointeractions of Nanomaterials. Florida: CRC Press; 2014. pp. 151. |
| 137. | Xiang QY, Wang MT, Chen F, Gong T, Jian YL, Zhang ZR, et al. Lung-targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles. Arch Pharm Res. 2007;30(4):519-525. |
[Figure 1]
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5], [Table 6], [Table 7]
| This article has been cited by | | 1 |
Chitosan oligosaccharide/alginate nanoparticles as an effective carrier for astaxanthin with improving stability, in vitro oral bioaccessibility, and bioavailability |
|
| Feuangthit Niyamissara Sorasitthiyanukarn,Chawanphat Muangnoi,Pornchai Rojsitthisak,Pranee Rojsitthisak | | Food Hydrocolloids. 2022; 124: 107246 | | [Pubmed] | [DOI] | | | 2 |
Novel insights on extraction and encapsulation techniques of elderberry bioactive compounds |
|
| Shahida Anusha Siddiqui, Ali Ali Redha, Yasaman Esmaeili, Mohammad Mehdizadeh | | Critical Reviews in Food Science and Nutrition. 2022; : 1 | | [Pubmed] | [DOI] | | | 3 |
Nose-to-brain drug delivery for the treatment of Alzheimer’s Disease: Current advancements and challenges |
|
| Prabakaran A, Mukta Agrawal, Mithun Rajendra Dethe, Hafiz Ahmed, Awesh Yadav, Umesh Gupta, Amit Alexander | | Expert Opinion on Drug Delivery. 2022; | | [Pubmed] | [DOI] | | | 4 |
Synthesis and Potential Applications of Lipid Nanoparticles in Medicine |
|
| Ewelina Musielak, Agnieszka Feliczak-Guzik, Izabela Nowak | | Materials. 2022; 15(2): 682 | | [Pubmed] | [DOI] | | | 5 |
Ezetimibe-Loaded Nanostructured Lipid Carrier Based Formulation Ameliorates Hyperlipidaemia in an Experimental Model of High Fat Diet |
|
| Yogeeta O. Agrawal,Umesh B. Mahajan,Vinit V. Agnihotri,Mayur S. Nilange,Hitendra S. Mahajan,Charu Sharma,Shreesh Ojha,Chandragouda R. Patil,Sameer N. Goyal | | Molecules. 2021; 26(5): 1485 | | [Pubmed] | [DOI] | | | 6 |
Lipidic Matrixes Containing Clove Essential Oil: Biological Activity, Microstructural and Textural Studies |
|
| John Rojas,Sergio Cabrera,Julie Benavides,Yasmín Lopera,Cristhian J. Yarce | | Molecules. 2021; 26(9): 2425 | | [Pubmed] | [DOI] | | | 7 |
Nanostructured Lipid Carrier–Mediated Transdermal Delivery of Aceclofenac Hydrogel Present an Effective Therapeutic Approach for Inflammatory Diseases |
|
| Neeraj K. Garg,Nikunj Tandel,Sanjay Kumar Bhadada,Rajeev K. Tyagi | | Frontiers in Pharmacology. 2021; 12 | | [Pubmed] | [DOI] | | | 8 |
An Overview on Topical Administration of Carotenoids and Coenzyme Q10 Loaded in Lipid Nanoparticles |
|
| Luciana de Souza Guedes,Renata Miliani Martinez,Nádia A. Bou-Chacra,Maria Valéria Robles Velasco,Catarina Rosado,André Rolim Baby | | Antioxidants. 2021; 10(7): 1034 | | [Pubmed] | [DOI] | | | 9 |
Inorganic and Polymeric Nanoparticles for Human Viral and Bacterial Infections Prevention and Treatment |
|
| John Jairo Aguilera-Correa,Jaime Esteban,María Vallet-Regí | | Nanomaterials. 2021; 11(1): 137 | | [Pubmed] | [DOI] | | | 10 |
Recent Advances in Lipid-Based Nanosystems for Gemcitabine and Gemcitabine–Combination Therapy |
|
| Saffiya Habib,Moganavelli Singh | | Nanomaterials. 2021; 11(3): 597 | | [Pubmed] | [DOI] | | | 11 |
A Multifunctional Polymeric Micelle for Targeted Delivery of Paclitaxel by the Inhibition of the P-Glycoprotein Transporters |
|
| Sobia Razzaq, Aisha Rauf, Abida Raza, Sohail Akhtar, Tanveer A. Tabish, Mansur Abdullah Sandhu, Muhammad Zaman, Ibrahim M. Ibrahim, Gul Shahnaz, Abbas Rahdar, Ana M. Díez-Pascual | | Nanomaterials. 2021; 11(11): 2858 | | [Pubmed] | [DOI] | | | 12 |
The Evaluation of Drug Delivery Nanocarrier Development and Pharmacological Briefing for Metabolic-Associated Fatty Liver Disease (MAFLD): An Update |
|
| Reem Abou Assi,Ibrahim M. Abdulbaqi,Chan Siok Yee | | Pharmaceuticals. 2021; 14(3): 215 | | [Pubmed] | [DOI] | | | 13 |
In Vitro Studies on Nasal Formulations of Nanostructured Lipid Carriers (NLC) and Solid Lipid Nanoparticles (SLN) |
|
| Cláudia Pina Costa,Sandra Barreiro,João Nuno Moreira,Renata Silva,Hugo Almeida,José Manuel Sousa Lobo,Ana Catarina Silva | | Pharmaceuticals. 2021; 14(8): 711 | | [Pubmed] | [DOI] | | | 14 |
Dermal Drug Delivery of Phytochemicals with Phenolic Structure via Lipid-Based Nanotechnologies |
|
| Viliana Gugleva,Nadezhda Ivanova,Yoana Sotirova,Velichka Andonova | | Pharmaceuticals. 2021; 14(9): 837 | | [Pubmed] | [DOI] | | | 15 |
Formulation and Evaluation of Valsartan Solid Lipid Nanoparticles |
|
| M. Chandana,M. Venkata Ramana,N. Rama Rao | | Journal of Drug Delivery and Therapeutics. 2021; 11(2-S): 103 | | [Pubmed] | [DOI] | | | 16 |
Protein-Based Nanohydrogels for Bioactive Delivery |
|
| Subhash Chander,Giriraj T. Kulkarni,Neerupma Dhiman,Harsha Kharkwal | | Frontiers in Chemistry. 2021; 9 | | [Pubmed] | [DOI] | | | 17 |
Viral Mimicry as a Design Template for Nucleic Acid Nanocarriers |
|
| Ina F. de la Fuente,Shraddha S. Sawant,Mark Q. Tolentino,Patrick M. Corrigan,Jessica L. Rouge | | Frontiers in Chemistry. 2021; 9 | | [Pubmed] | [DOI] | | | 18 |
Polymers Blending as Release Modulating Tool in Drug Delivery |
|
| Parisa Ghasemiyeh, Soliman Mohammadi-Samani | | Frontiers in Materials. 2021; 8 | | [Pubmed] | [DOI] | | | 19 |
Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer? |
|
| Roseane Guimarães Ferreira,Luis Eduardo Mosquera Narvaez,Kaio Murilo Monteiro Espíndola,Amanda Caroline R. S. Rosario,Wenddy Graziela N. Lima,Marta Chagas Monteiro | | Frontiers in Oncology. 2021; 11 | | [Pubmed] | [DOI] | | | 20 |
Solid Lipid Nanoparticles as Carriers for the Synthetic Opioid LP2: Characterization and In Vitro Release |
|
| Angelo Spadaro, Lorella Pasquinucci, Miriam Lorenti, Ludovica Maria Santagati, Maria Grazia Sarpietro, Rita Turnaturi, Carmela Parenti, Lucia Montenegro | | Applied Sciences. 2021; 11(21): 10250 | | [Pubmed] | [DOI] | | | 21 |
Trends in Nanotechnology and Its Potentialities to Control Plant Pathogenic Fungi: A Review |
|
| Abdulaziz Bashir Kutawa,Khairulmazmi Ahmad,Asgar Ali,Mohd Zobir Hussein,Mohd Aswad Abdul Wahab,Abdullahi Adamu,Abubakar A. Ismaila,Mahesh Tiran Gunasena,Muhammad Ziaur Rahman,Md Imam Hossain | | Biology. 2021; 10(9): 881 | | [Pubmed] | [DOI] | | | 22 |
Advanced Nanoparticle-Based Drug Delivery Systems and Their Cellular Evaluation for Non-Small Cell Lung Cancer Treatment |
|
| Noratiqah Mohtar,Thaigarajan Parumasivam,Amirah Mohd Gazzali,Chu Shan Tan,Mei Lan Tan,Rozana Othman,Siti Sarah Fazalul Rahiman,Habibah A. Wahab | | Cancers. 2021; 13(14): 3539 | | [Pubmed] | [DOI] | | | 23 |
Hyaluronic Acid-Functionalized Nanomicelles Enhance SAHA Efficacy in 3D Endometrial Cancer Models |
|
| Kadie Edwards,Seydou Yao,Simone Pisano,Veronica Feltracco,Katja Brusehafer,Sumanta Samanta,Oommen P. Oommen,S. Andrea Gazze,Roberta Paravati,Holly Maddison,Chao Li,Deyarina Gonzalez,R. Steven Conlan,Lewis Francis | | Cancers. 2021; 13(16): 4032 | | [Pubmed] | [DOI] | | | 24 |
Do Lipid-based Nanoparticles Hold Promise for Advancing the Clinical Translation of Anticancer Alkaloids? |
|
| Jian Sheng Loh, Li Kar Stella Tan, Wai Leng Lee, Long Chiau Ming, Chee Wun How, Jhi Biau Foo, Nurolaini Kifli, Bey Hing Goh, Yong Sze Ong | | Cancers. 2021; 13(21): 5346 | | [Pubmed] | [DOI] | | | 25 |
Design, Preparation, and Characterization of Effective Dermal and Transdermal Lipid Nanoparticles: A Review |
|
| Dima Khater,Hamdi Nsairat,Fadwa Odeh,Mais Saleh,Areej Jaber,Walhan Alshaer,Abeer Al Bawab,Mohammad S. Mubarak | | Cosmetics. 2021; 8(2): 39 | | [Pubmed] | [DOI] | | | 26 |
Lipid larceny: channelizing host lipids for establishing successful pathogenesis by bacteria |
|
| Ritika Chatterjee,Atish Roy Chowdhury,Debapriya Mukherjee,Dipshikha Chakravortty | | Virulence. 2021; 12(1): 195 | | [Pubmed] | [DOI] | | | 27 |
Pharmaceutical evaluation of atorvastatin-loaded nanostructured lipid carriers incorporated into the gelatin/hyaluronic acid/polycaprolactone scaffold for the skin tissue engineering |
|
| Mahsa Ahmadi,Mehdi Mehdikhani,Jaleh Varshosaz,Shadi Farsaei,Hadis Torabi | | Journal of Biomaterials Applications. 2021; 35(8): 958 | | [Pubmed] | [DOI] | | | 28 |
Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls |
|
| Morteza Heidarzadeh,Yasemin Gürsoy-Özdemir,Mehmet Kaya,Aysan Eslami Abriz,Amir Zarebkohan,Reza Rahbarghazi,Emel Sokullu | | Cell & Bioscience. 2021; 11(1) | | [Pubmed] | [DOI] | | | 29 |
Preparation and evaluation of adapalene nanostructured lipid carriers for targeted drug delivery in acne |
|
| Saman Ahmad Nasrollahi,Faezeh Koohestani,Atefeh Naeimifar,Aniseh Samadi,Alireza Vatanara,Alireza Firooz | | Dermatologic Therapy. 2021; | | [Pubmed] | [DOI] | | | 30 |
Drug Delivery of Natural Products Through Nanocarriers for Effective Breast Cancer Therapy: A Comprehensive Review of Literature |
|
| Kah Min Yap, Mahendran Sekar, Shivkanya Fuloria, Yuan Seng Wu, Siew Hua Gan, Nur Najihah Izzati Mat Rani, Vetriselvan Subramaniyan, Chandrakant Kokare, Pei Teng Lum, M Yasmin Begum, Shankar Mani, Dhanalekshmi Unnikrishnan Meenakshi, Kathiresan V Sathasivam, Neeraj Kumar Fuloria | | International Journal of Nanomedicine. 2021; Volume 16: 7891 | | [Pubmed] | [DOI] | | | 31 |
Herbal Nanoformulations for Asthma Treatment |
|
| Jing Yang, Bo Song, Junzi Wu | | Current Pharmaceutical Design. 2021; 27 | | [Pubmed] | [DOI] | | | 32 |
Application of Poloxamers for the Development of Drug Delivery System to Treat Leishmaniasis: A Review |
|
| Audrey Silva, Amanda Costa, Sona Jain, Eduardo Coelho, Ricardo Fujiwara, Ricardo Scher, Rogéria Nunes, Silvio Dolabella | | Current Drug Targets. 2021; 22(3): 296 | | [Pubmed] | [DOI] | | | 33 |
Beyond DNA-targeting in Cancer Chemotherapy. Emerging Frontiers - A Review |
|
| Simon N. Mbugua,Lydia W. Njenga,Ruth A. Odhiambo,Shem O. Wandiga,Martin O. Onani | | Current Topics in Medicinal Chemistry. 2021; 21(1): 28 | | [Pubmed] | [DOI] | | | 34 |
Lipid-based nano-formulation platform for eplerenone oral delivery as a potential treatment of chronic central serous chorioretinopathy: in-vitro optimization and ex-vivo assessment |
|
| Eman Abd-Elhakeem,Mohamed El-Nabarawi,Rehab Shamma | | Drug Delivery. 2021; 28(1): 642 | | [Pubmed] | [DOI] | | | 35 |
A Recent Update on Drug Delivery Systems for Pain Management |
|
| Apoorva Phadke,Purnima Amin | | Journal of Pain & Palliative Care Pharmacotherapy. 2021; : 1 | | [Pubmed] | [DOI] | | | 36 |
Nanotherapeutics approaches for targeting alpha synuclien protein in the management of Parkinson disease |
|
| Ajit Singh,Sandeep Kumar Maharana,Rahul Shukla,Prashant Kesharwani | | Process Biochemistry. 2021; | | [Pubmed] | [DOI] | | | 37 |
Encapsulation of probiotics and nutraceuticals: Applications in functional food industry |
|
| Priscilla Magro Reque,Adriano Brandelli | | Trends in Food Science & Technology. 2021; 114: 1 | | [Pubmed] | [DOI] | | | 38 |
Coalition of Biological Agent (Melatonin) With Chemotherapeutic Agent (Amphotericin B) for Combating Visceral Leishmaniasis via Oral Administration of Modified Solid Lipid Nanoparticles |
|
| Shabi Parvez,Ganesh Yadagiri,Kanika Arora,Aaqib Javaid,Anurag Kumar Kushwaha,Om Prakash Singh,Shyam Sundar,Shyam Lal Mudavath | | ACS Biomaterials Science & Engineering. 2021; | | [Pubmed] | [DOI] | | | 39 |
Design of Hepatic Targeted Drug Delivery Systems for Natural Products: Insights into Nomenclature Revision of Nonalcoholic Fatty Liver Disease |
|
| Rou Tang, Rui Li, He Li, Xiao-Lei Ma, Peng Du, Xiao-You Yu, Ling Ren, Lu-Lu Wang, Wen-Sheng Zheng | | ACS Nano. 2021; 15(11): 17016 | | [Pubmed] | [DOI] | | | 40 |
Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects |
|
| Ummu Umaimah Mohd Nordin,Noraini Ahmad,Norazlinaliza Salim,Nor Saadah Mohd Yusof | | RSC Advances. 2021; 11(46): 29080 | | [Pubmed] | [DOI] | | | 41 |
Biosynthesis and characterisation of solid lipid nanoparticles and investigation of toxicity against breast cancer cell line |
|
| Mohammad Sharifalhoseini,Ali Es-haghi,Gholamhassan Vaezi,Hooman Shajiee | | IET Nanobiotechnology. 2021; | | [Pubmed] | [DOI] | | | 42 |
Bortezomib-loaded lipidic-nano drug delivery systems; formulation, therapeutic efficacy, and pharmacokinetics |
|
| Mohammad Mahmoudian,Hadi Valizadeh,Raimar Löbenberg,Parvin Zakeri-Milani | | Journal of Microencapsulation. 2021; : 1 | | [Pubmed] | [DOI] | | | 43 |
Nano-Lipidic Formulation and Therapeutic Strategies for Alzheimer’s disease via Intranasal Route |
|
| Shourya Tripathi,Ujala Gupta,Rewati Raman Ujjwal,Awesh K. Yadav | | Journal of Microencapsulation. 2021; : 1 | | [Pubmed] | [DOI] | | | 44 |
Lipid nanostructures for targeting brain cancer |
|
| Hamdi Nsairat,Dima Khater,Fadwa Odeh,Fedaa Al-Adaileh,Suma Al-Taher,Areej M. Jaber,Walhan Alshaer,Abeer Al Bawab,Mohammad S. Mubarak | | Heliyon. 2021; 7(9): e07994 | | [Pubmed] | [DOI] | | | 45 |
Antibody Conjugated Lipid Nanoparticles as a Targeted Drug Delivery System for Hydrophobic Pharmaceuticals |
|
| Martine K. Notabi,Eva C. Arnspang,Morten Ø. Andersen | | European Journal of Pharmaceutical Sciences. 2021; : 105777 | | [Pubmed] | [DOI] | | | 46 |
Recent advances in encapsulation technologies of kenaf (Hibiscus cannabinus) leaves and seeds for cosmeceutical application |
|
| Chee Chin Chu,Sook Chin Chew,Kar Lin Nyam | | Food and Bioproducts Processing. 2021; | | [Pubmed] | [DOI] | | | 47 |
Bioactive glass: A multifunctional delivery system |
|
| Smriti Gupta,Shreyasi Majumdar,Sairam Krishnamurthy | | Journal of Controlled Release. 2021; | | [Pubmed] | [DOI] | | | 48 |
Nanotechnology against COVID-19: Immunization, diagnostic and therapeutic studies |
|
| Akbar Hasanzadeh,Masoomeh Alamdaran,Sepideh Ahmadi,Helena Nourizadeh,Mohammad Aref Bagherzadeh,Mirza Ali Mofazzal Jahromi,Perikles Simon,Mahdi Karimi,Michael R. Hamblin | | Journal of Controlled Release. 2021; | | [Pubmed] | [DOI] | | | 49 |
Lipid nanoparticles with improved biopharmaceutical attributes for tuberculosis treatment |
|
| Aldemar Gordillo-Galeano,Luis Fernando Ospina-Giraldo,Claudia Elizabeth Mora-Huertas | | International Journal of Pharmaceutics. 2021; 596: 120321 | | [Pubmed] | [DOI] | | | 50 |
Vegetable oils in pharmaceutical and cosmetic lipid-based nanocarriers preparations |
|
| Jéssica Fagionato Masiero,Eduardo José Barbosa,Luiza de Oliveira Macedo,Aline de Souza,Megumi Nishitani Yukuyama,Geraldo José Arantes,Nádia Araci Bou-Chacra | | Industrial Crops and Products. 2021; 170: 113838 | | [Pubmed] | [DOI] | | | 51 |
Combination antipsychotics therapy for schizophrenia and related psychotic disorders interventions: Emergence to nanotechnology and herbal drugs |
|
| Akram Annu,Sanjula Baboota,Javed Ali | | Journal of Drug Delivery Science and Technology. 2021; 61: 102272 | | [Pubmed] | [DOI] | | | 52 |
Nose to brain delivery of Rotigotine loaded solid lipid nanoparticles: Quality by Design based optimization and characterization |
|
| Jagruti B. Prajapati,Gayatri C. Patel | | Journal of Drug Delivery Science and Technology. 2021; : 102377 | | [Pubmed] | [DOI] | | | 53 |
Understanding the implications of co-delivering therapeutic agents in a nanocarrier to combat multidrug resistance (MDR) in breast cancer |
|
| Aditi Fulfager,Khushwant S. Yadav | | Journal of Drug Delivery Science and Technology. 2021; : 102405 | | [Pubmed] | [DOI] | | | 54 |
Recent updates in COVID-19 with emphasis on inhalation therapeutics: nanostructured and targeting systems |
|
| Ahmed A.H. Abdellatif,Hesham M. Tawfeek,Ahmed Abdelfattah,Gaber El-Saber Batiha,Helal F. Hetta | | Journal of Drug Delivery Science and Technology. 2021; : 102435 | | [Pubmed] | [DOI] | | | 55 |
Ceftriaxone sodium loaded onto polymer-lipid hybrid nanoparticles enhances antibacterial effect on gram-negative and gram-positive bacteria: Effects of lipid - polymer ratio on particles size, characteristics, in vitro drug release and antibacterial drug efficacy |
|
| Arash Rigi Hossein abadi,Nafiseh Farhadian,Mohammad Karimi,Samaneh Porozan | | Journal of Drug Delivery Science and Technology. 2021; : 102457 | | [Pubmed] | [DOI] | | | 56 |
Lymphatic transport system to circumvent hepatic metabolism for oral delivery of lipid-based nanocarriers |
|
| Amarjitsing Rajput, Prashant Pingale, Darshan Telange, Shailesh Chalikwar, Vivek Borse | | Journal of Drug Delivery Science and Technology. 2021; 66: 102934 | | [Pubmed] | [DOI] | | | 57 |
Herbal medicine for ocular diseases: An age old therapy and its future perspective |
|
| Archana S. Pokkalath, Apurva Sawant, Sujata P. Sawarkar | | Journal of Drug Delivery Science and Technology. 2021; : 102979 | | [Pubmed] | [DOI] | | | 58 |
Features, Applications, and Sustainability of Lipid Nanoparticles in Cosmeceuticals |
|
| Mohyeddin Assali, Abdel-Naser Zaid | | Saudi Pharmaceutical Journal. 2021; | | [Pubmed] | [DOI] | | | 59 |
Breaking the barriers for the delivery of amikacin: Challenges, strategies, and opportunities |
|
| Amala Maxwell,Vivek Ghate,Jesil Aranjani,Shaila Lewis | | Life Sciences. 2021; : 119883 | | [Pubmed] | [DOI] | | | 60 |
Investigating natural antibiofilm components: a new therapeutic perspective against candidal vulvovaginitis |
|
| Nazia Hassan,Salma Firdaus,Santwana Padhi,Asgar Ali,Zeenat Iqbal | | Medical Hypotheses. 2021; : 110515 | | [Pubmed] | [DOI] | | | 61 |
Nano-based drug delivery systems used as vehicles to enhance polyphenols therapeutic effect for diabetes mellitus treatment |
|
| Sónia Rocha,Mariana Lucas,Daniela Ribeiro,M. Luísa Corvo,Eduarda Fernandes,Marisa Freitas | | Pharmacological Research. 2021; 169: 105604 | | [Pubmed] | [DOI] | | | 62 |
Preparation a
core-shell
lipid/polymer nanoparticle containing Isotretinoin drug with
pH
sensitive property: A response surface methodology study |
|
| Tahereh Najafi Ghaghelestani,Nafiseh Farhadian,Nafiseh Binesh | | Journal of Applied Polymer Science. 2021; : 50734 | | [Pubmed] | [DOI] | | | 63 |
Polymeric nanoencapsulation of zaleplon into PLGA nanoparticles for enhanced pharmacokinetics and pharmacological activity |
|
| Yusuf A. Haggag,Ahmed Kh. Abosalha,Murtaza M. Tambuwala,Enass Y. Osman,Sanaa A. El-Gizawy,Ebtessam A. Essa,Ahmed A. Donia | | Biopharmaceutics & Drug Disposition. 2021; | | [Pubmed] | [DOI] | | | 64 |
Novel strategies to oral delivery of insulin: Current progress of nanocarriers for diabetes management |
|
| Adel Abdel-Moneim, Hanaa Ramadan | | Drug Development Research. 2021; | | [Pubmed] | [DOI] | | | 65 |
A Film-Forming System Hybridized with a Nanostructured Chloroacetamide Derivative for Dermatophytosis Treatment |
|
| Gabriella R. M. Machado,Luiz A. M. Inácio,Simone J. Berlitz,Bruna Pippi,Irene C. Kulkamp-Guerreiro,Stefânia N. Lavorato,Ricardo J. Alves,Saulo F. Andrade,Alexandre M. Fuentefria | | ChemistrySelect. 2021; 6(33): 8527 | | [Pubmed] | [DOI] | | | 66 |
Lipid nanoparticles for the transport of drugs like dopamine through the blood-brain barrier |
|
| Elena Ortega,Santos Blanco,Adolfina Ruiz,María Ángeles Peinado,Sebastián Peralta,María Encarnación Morales | | Journal of Nanoparticle Research. 2021; 23(4) | | [Pubmed] | [DOI] | | | 67 |
Nano-fats for bugs: the benefits of lipid nanoparticles for antimicrobial therapy |
|
| Chelsea R. Thorn,Nicky Thomas,Ben J. Boyd,Clive A. Prestidge | | Drug Delivery and Translational Research. 2021; | | [Pubmed] | [DOI] | | | 68 |
The combination of nanotechnology and traditional Chinese medicine (TCM) inspires the modernization of TCM: review on nanotechnology in TCM-based drug delivery systems |
|
| Yinghao Zheng,Yun Wang,Mengyu Xia,Ya Gao,Lan Zhang,Yanan Song,Cun Zhang | | Drug Delivery and Translational Research. 2021; | | [Pubmed] | [DOI] | | | 69 |
Nanomedicine-based antimicrobial peptide delivery for bacterial infections: recent advances and future prospects |
|
| Raj Kumar Thapa,Dzung B. Diep,Hanne Hjorth Tønnesen | | Journal of Pharmaceutical Investigation. 2021; | | [Pubmed] | [DOI] | | | 70 |
Multifunctional lipidic nanocarriers for effective therapy of glioblastoma: recent advances in stimuli-responsive, receptor and subcellular targeted approaches |
|
| Manasa Manjunath Hegde, Suma Prabhu, Srinivas Mutalik, Abhishek Chatterjee, Jayant S. Goda, B. S. Satish Rao | | Journal of Pharmaceutical Investigation. 2021; | | [Pubmed] | [DOI] | | | 71 |
Nanotechnology-based Delivery of CRISPR/Cas9 for Cancer Treatment |
|
| Xiaoyu Xu,Chang Liu,Yonghui Wang,Oliver Koivisto,Junnian Zhou,Yilai Shu,Hongbo Zhang | | Advanced Drug Delivery Reviews. 2021; : 113891 | | [Pubmed] | [DOI] | | | 72 |
CRISPR/Cas9 Ribonucleoprotein-Mediated Genome and Epigenome Editing in Mammalian Cells |
|
| Hanan Bloomer, Jennifer Khirallah, Yamin Li, Qiaobing Xu | | Advanced Drug Delivery Reviews. 2021; : 114087 | | [Pubmed] | [DOI] | | | 73 |
Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies |
|
| Cláudia Pina Costa,João Nuno Moreira,José Manuel Sousa Lobo,Ana Catarina Silva | | Acta Pharmaceutica Sinica B. 2021; | | [Pubmed] | [DOI] | | | 74 |
Nanomedicines: Redefining traditional medicine |
|
| Weijia Lu,Jing Yao,Xiao Zhu,Yi Qi | | Biomedicine & Pharmacotherapy. 2021; 134: 111103 | | [Pubmed] | [DOI] | | | 75 |
Auraptene nanoparticles ameliorate testosterone-induced benign prostatic hyperplasia in rats: Emphasis on antioxidant, anti-inflammatory, proapoptotic and PPARs activation effects |
|
| Haifa Almukadi,Basma G. Eid,Rasheed A. Shaik,Ashraf B. Abdel-Naim,Ahmed Esmat | | Biomedicine & Pharmacotherapy. 2021; 143: 112199 | | [Pubmed] | [DOI] | | | 76 |
Structured edible lipid-based particle systems for oral drug-delivery |
|
| Areen Ashkar,Alejandro Sosnik,Maya Davidovich-Pinhas | | Biotechnology Advances. 2021; : 107789 | | [Pubmed] | [DOI] | | | 77 |
Prospects and challenges of anticancer agentsæ delivery via chitosan-based drug carriers to combat breast cancer: A review |
|
| Guiqiu Wang,Rilun Li,Benyamin Parseh,Gang Du | | Carbohydrate Polymers. 2021; : 118192 | | [Pubmed] | [DOI] | | | 78 |
Biomaterials for Orthopaedic Diagnostics and Theranostics |
|
| Marian A. Ackun-Farmmer,Clyde T. Overby,Brittany E. Haws,Regine Choe,Danielle S.W. Benoit | | Current Opinion in Biomedical Engineering. 2021; : 100308 | | [Pubmed] | [DOI] | | | 79 |
Solid Lipid Nanoparticles and Nanostructured Lipid Carriers of natural products as promising systems for their bioactivity enhancement: The case of essential oils and flavonoids |
|
| Annita Katopodi,Anastasia Detsi | | Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2021; 630: 127529 | | [Pubmed] | [DOI] | | | 80 |
Supramolecular lipid nanoparticles as delivery carriers for non-invasive cancer theranostics |
|
| Syeda Zunaira Bukhari, Kornelius Zeth, Maryam Iftikhar, Mubashar Rehman, Muhammad Usman Munir, Waheed S. Khan, Ayesha Ihsan | | Current Research in Pharmacology and Drug Discovery. 2021; 2: 100067 | | [Pubmed] | [DOI] | | | 81 |
Recent advances in nano delivery systems for blood-brain barrier (BBB) penetration and targeting of brain tumors |
|
| Shriya Reddy,Katyayani Tatiparti,Samaresh Sau,Arun K. Iyer | | Drug Discovery Today. 2021; | | [Pubmed] | [DOI] | | | 82 |
Recent update of toxicity aspects of nanoparticulate systems for drug delivery |
|
| Soma Patnaik,Bapi Gorain,Santwana Padhi,Hira Choudhury,Gamal A. Gabr,Shadab Md,Dinesh Kumar Mishra,Prashant Kesharwani | | European Journal of Pharmaceutics and Biopharmaceutics. 2021; | | [Pubmed] | [DOI] | | | 83 |
Osteosarcoma from the unknown to the use of exosomes as a versatile and dynamic therapeutic approach |
|
| Ana Santos, Cátia Domingues, Ivana Jarak, Francisco Veiga, Ana Figueiras | | European Journal of Pharmaceutics and Biopharmaceutics. 2021; | | [Pubmed] | [DOI] | | | 84 |
Naringenin Nano-Delivery Systems and Their Therapeutic Applications |
|
| Mohammed Bhia,Mahzad Motallebi,Banafshe Abadi,Atefeh Zarepour,Miguel Pereira-Silva,Farinaz Saremnejad,Ana Cláudia Santos,Ali Zarrabi,Ana Melero,Seid Mahdi Jafari,Mehdi Shakibaei | | Pharmaceutics. 2021; 13(2): 291 | | [Pubmed] | [DOI] | | | 85 |
Developing Actively Targeted Nanoparticles to Fight Cancer: Focus on Italian Research |
|
| Monica Argenziano,Silvia Arpicco,Paola Brusa,Roberta Cavalli,Daniela Chirio,Franco Dosio,Marina Gallarate,Elena Peira,Barbara Stella,Elena Ugazio | | Pharmaceutics. 2021; 13(10): 1538 | | [Pubmed] | [DOI] | | | 86 |
Nose to Brain Delivery of Phenytoin Sodium Loaded Nano Lipid Carriers: Formulation, Drug Release, Permeation and In Vivo Pharmacokinetic Studies |
|
| Sreeja C. Nair,Kollencheri Puthenveettil Vinayan,Sabitha Mangalathillam | | Pharmaceutics. 2021; 13(10): 1640 | | [Pubmed] | [DOI] | | | 87 |
Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier |
|
| David Lee, Tamara Minko | | Pharmaceutics. 2021; 13(12): 2049 | | [Pubmed] | [DOI] | | | 88 |
Cyclodextrin-Modified Nanomaterials for Drug Delivery: Classification and Advances in Controlled Release and Bioavailability |
|
| Daniel Andrés Real, Karen Bolaños, Josefina Priotti, Nicolás Yutronic, Marcelo J. Kogan, Rodrigo Sierpe, Orlando Donoso-González | | Pharmaceutics. 2021; 13(12): 2131 | | [Pubmed] | [DOI] | | | 89 |
Novel Selectively Targeted Multifunctional Nanostructured Lipid Carriers for Prostate Cancer Treatment |
|
| Lital Cohen, Yehuda G. Assaraf, Yoav D. Livney | | Pharmaceutics. 2021; 14(1): 88 | | [Pubmed] | [DOI] | | | 90 |
Use of nanosystems to improve the anticancer effects of curcumin |
|
| Andrea M Araya-Sibaja,Norma J Salazar-López,Krissia Wilhelm Romero,José R Vega-Baudrit,J Abraham Domínguez-Avila,Carlos A Velázquez Contreras,Ramón E Robles-Zepeda,Mirtha Navarro-Hoyos,Gustavo A González-Aguilar | | Beilstein Journal of Nanotechnology. 2021; 12: 1047 | | [Pubmed] | [DOI] | | | 91 |
Duck Oil-loaded Nanoemulsion Inhibits Senescence of Angiotensin
II-treated Vascular Smooth Muscle Cells by Upregulating SIRT1 |
|
| Eun Sil Kang,Hyo Juong Kim,Sung Gu Han,Han Geuk Seo | | Food Science of Animal Resources. 2020; 40(1): 106 | | [Pubmed] | [DOI] | | | 92 |
Recent Developments in Microfluidic Technologies for Central Nervous System Targeted Studies |
|
| Maria Inês Teixeira,Maria Helena Amaral,Paulo C. Costa,Carla M. Lopes,Dimitrios A. Lamprou | | Pharmaceutics. 2020; 12(6): 542 | | [Pubmed] | [DOI] | | | 93 |
Nanoparticles Formulations of Artemisinin and Derivatives as Potential Therapeutics for the Treatment of Cancer, Leishmaniasis and Malaria |
|
| Sibusiso Alven,Blessing Atim Aderibigbe | | Pharmaceutics. 2020; 12(8): 748 | | [Pubmed] | [DOI] | | | 94 |
Liquid and Solid Self-Emulsifying Drug Delivery Systems (SEDDs) as Carriers for the Oral Delivery of Azithromycin: Optimization, In Vitro Characterization and Stability Assessment |
|
| Reem Abou Assi,Ibrahim M. Abdulbaqi,Toh Seok Ming,Chan Siok Yee,Habibah A. Wahab,Shaik Mohammed Asif,Yusrida Darwis | | Pharmaceutics. 2020; 12(11): 1052 | | [Pubmed] | [DOI] | | | 95 |
Towards Robust Delivery of Antimicrobial Peptides to Combat Bacterial Resistance |
|
| Matthew Drayton,Jayachandran N. Kizhakkedathu,Suzana K. Straus | | Molecules. 2020; 25(13): 3048 | | [Pubmed] | [DOI] | | | 96 |
Emerging vaccine delivery systems for COVID-19 |
|
| Nigel Theobald | | Drug Discovery Today. 2020; | | [Pubmed] | [DOI] | | | 97 |
Low temperature, easy scaling upmethod for development of smart nanostructure hybrid lipid capsulesfor drug delivery application |
|
| Sunil Kumar Yadava,Suparna Mercy Basu,Meenakshi Chauhan,Kshipra Sharma,Apran Pradhan,Remya V.,Jyotsnendu Giri | | Colloids and Surfaces B: Biointerfaces. 2020; : 110927 | | [Pubmed] | [DOI] | | | 98 |
Enhanced In Vitro Antimicrobial Activity of Polymyxin B–Coated Nanostructured Lipid Carrier Containing Dexamethasone Acetate |
|
| Emmily Dantas Rocha,Marcia Regina Spuri Ferreira,Edson dos Santos Neto,Eduardo José Barbosa,Raimar Löbenberg,Felipe Rebello Lourenço,Nadia Bou-Chacra | | Journal of Pharmaceutical Innovation. 2020; | | [Pubmed] | [DOI] | | | 99 |
Chitosan-based particulate systems for drug and vaccine delivery in the treatment and prevention of neglected tropical diseases |
|
| Sevda Senel,Selin Yüksel | | Drug Delivery and Translational Research. 2020; | | [Pubmed] | [DOI] | | | 100 |
Nanomedicine progress in thrombolytic therapy |
|
| Alina Zenych,Louise Fournier,Cédric Chauvierre | | Biomaterials. 2020; 258: 120297 | | [Pubmed] | [DOI] | | | 101 |
Stabilized oral nanostructured lipid carriers of Adefovir Dipivoxil as a potential liver targeting: Estimation of liver function panel and uptake following intravenous injection of radioiodinated indicator |
|
| Shady M. Abd El-Halim,Ghada A. Abdelbary,Maha M. Amin,Mohamed Y. Zakaria,Hesham A. Shamsel-Din,Ahmed B. Ibrahim | | DARU Journal of Pharmaceutical Sciences. 2020; | | [Pubmed] | [DOI] | | | 102 |
Nanoparticles for drug delivery in Parkinson’s disease |
|
| Jonathan Baskin,June Evelyn Jeon,Simon J. G. Lewis | | Journal of Neurology. 2020; | | [Pubmed] | [DOI] | | | 103 |
Conjugated linoleic acid loaded nanostructured lipid carrier as a potential antioxidant nanocarrier for food applications |
|
| Fatemeh Sadat Hashemi,Farin Farzadnia,Abdoreza Aghajani,Farnaz Ahmadzadeh NobariAzar,Akram Pezeshki | | Food Science & Nutrition. 2020; | | [Pubmed] | [DOI] | | | 104 |
Therapeutic benefits of rutin and its nanoformulations |
|
| Ramin Negahdari,Sepideh Bohlouli,Simin Sharifi,Solmaz Maleki Dizaj,Yalda Rahbar Saadat,Khadijeh Khezri,Samira Jafari,Elham Ahmadian,Negar G. Jahandizi,Safa Raeesi | | Phytotherapy Research. 2020; | | [Pubmed] | [DOI] | | | 105 |
Green Algae as a Drug Delivery System for the Controlled Release of Antibiotics |
|
| Inga S. Shchelik,Simon Sieber,Karl Gademann | | Chemistry – A European Journal. 2020; | | [Pubmed] | [DOI] | | | 106 |
Advances in edible nanoemulsions: Digestion, bioavailability, and potential toxicity |
|
| David Julian McClements | | Progress in Lipid Research. 2020; : 101081 | | [Pubmed] | [DOI] | | | 107 |
Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment |
|
| João Basso,Maria Mendes,Jessica Silva,José Sereno,Tânia Cova,Rui Oliveira,Ana Fortuna,Miguel Castelo-Branco,Amílcar Falcão,João Sousa,Alberto Pais,Carla Vitorino | | European Journal of Pharmaceutics and Biopharmaceutics. 2020; | | [Pubmed] | [DOI] | | | 108 |
Zein coated calcium carbonate nanoparticles for the targeted controlled release of model antibiotic and nutrient across the intestine |
|
| Meenakshi Gautam,Deenan Santhiya,Namit Dey | | Materials Today Communications. 2020; 25: 101394 | | [Pubmed] | [DOI] | | | 109 |
Nanomaterials as potential transporters of HDAC inhibitors |
|
| Cristabelle De Souza,Aaron Raymond Lindstrom,Zhao Ma,Biswa Prasun Chatterji | | Medicine in Drug Discovery. 2020; : 100040 | | [Pubmed] | [DOI] | | | 110 |
A Short review on the antimicrobial micro- and nanoparticles loaded with Melaleuca alternifolia essential oil |
|
| Mariana Alves Battisti,Thiago Caon,Angela Machado de Campos | | Journal of Drug Delivery Science and Technology. 2020; : 102283 | | [Pubmed] | [DOI] | | | 111 |
Nasal administration of nanoencapsulated geraniol/ursodeoxycholic acid conjugate: Towards a new approach for the management of Parkinsonæs disease |
|
| Edilson Ribeiro de Oliveira Junior,Eleonora Truzzi,Luca Ferraro,Marco Fogagnolo,Barbara Pavan,Sarah Beggiato,Cecilia Rustichelli,Eleonora Maretti,Eliana Martins Lima,Eliana Leo,Alessandro Dalpiaz | | Journal of Controlled Release. 2020; | | [Pubmed] | [DOI] | | | 112 |
Squalene integrated NLC based gel of tamoxifen citrate for efficient treatment of psoriasis: A preclinical investigation |
|
| Amit Sharma,Deepak Kumar Upadhyay,Ganti Subrahmanya Sarma,Navjot Kaur,Ghanshyam Das Gupta,Raj Kumar Narang,Vineet Kumar Rai | | Journal of Drug Delivery Science and Technology. 2020; : 101568 | | [Pubmed] | [DOI] | | | 113 |
A comprehensive review of nano drug delivery system in the treatment of CNS disorders |
|
| K.M. Asha Spandana,Mahendran Bhaskaran,V.V.S.N.Reddy Karri,Jawahar Natarajan | | Journal of Drug Delivery Science and Technology. 2020; : 101628 | | [Pubmed] | [DOI] | | | 114 |
Drug delivery systems integrated with conventional and advanced treatment approaches toward cellulite reduction |
|
| Sara A. Abosabaa,Mona G. Arafa,Aliaa Nabil ElMeshad | | Journal of Drug Delivery Science and Technology. 2020; : 102084 | | [Pubmed] | [DOI] | | | 115 |
Development of respirable rifampicin loaded bovine serum albumin formulation for the treatment of pulmonary tuberculosis |
|
| Monica Joshi,Bala Prabhakar | | Journal of Drug Delivery Science and Technology. 2020; : 102197 | | [Pubmed] | [DOI] | | | 116 |
Novel nanotechnology approaches for diagnosis and therapy of breast, ovarian and cervical cancer in female: A review |
|
| Ameeduzzafar Zafar,Nabil K. Alruwaili,Syed Sarim Imam,Khalid Saad Alharbi,Muhammad Afzal,Nasser Hadal Alotaibi,Mohd Yasir,Mohammed Elmowafy,Sultan Alshehri | | Journal of Drug Delivery Science and Technology. 2020; : 102198 | | [Pubmed] | [DOI] | | | 117 |
Development of lipid nanoparticles containing the xanthone LEM2 for topical treatment of melanoma |
|
| Rafaela Malta,Joana B. Loureiro,Paulo Costa,Emília Sousa,Madalena Pinto,Lucília Saraiva,M. Helena Amaral | | Journal of Drug Delivery Science and Technology. 2020; : 102226 | | [Pubmed] | [DOI] | | | 118 |
Engineering approaches for drug delivery systems production and characterization |
|
| A.A. Barba,A. Dalmoro,S. Bochicchio,V. De Simone,D. Caccavo,M. Iannone,G. Lamberti | | International Journal of Pharmaceutics. 2020; : 119267 | | [Pubmed] | [DOI] | | | 119 |
The uses of resveratrol for neurological diseases treatment and insights for nanotechnology based-drug delivery systems |
|
| Bruno Fonseca-Santos,Marlus Chorilli | | International Journal of Pharmaceutics. 2020; 589: 119832 | | [Pubmed] | [DOI] | | | 120 |
Design of nalidixic acid-vanadium complex loaded into chitosan hybrid nanoparticles as smart strategy to inhibit bacterial growth and quorum sensing |
|
| Bárbara Bueloni,Daniele Sanna,Eugenio Garribba,Guillermo R. Castro,Ignacio E. León,Germán A. Islan | | International Journal of Biological Macromolecules. 2020; 161: 1568 | | [Pubmed] | [DOI] | | | 121 |
Management of epileptic disorders using nanotechnology-based strategies for nose-to-brain drug delivery |
|
| Mihika Shringarpure,Sankalp Gharat,Munira Momin,Abdelwahab Omri | | Expert Opinion on Drug Delivery. 2020; | | [Pubmed] | [DOI] | | | 122 |
The advantages of nanomedicine in the treatment of visceral leishmaniasis: between sound arguments and wishful thinking |
|
| Kevin Matha,Brice Calvignac,Jean-Pierre Gangneux,Jean-Pierre Benoit | | Expert Opinion on Drug Delivery. 2020; : 1 | | [Pubmed] | [DOI] | | | 123 |
Effect of nanostructured lipid carriers on transdermal delivery of tenoxicam in irradiated rats |
|
| Saud Bawazeer,Dalia Farag A. El-Telbany,Majid Mohammad Al-Sawahli,Gamal Zayed,Ahmed Abdallah A. Keed,Abdelaziz E. Abdelaziz,Doaa H. Abdel-Naby | | Drug Delivery. 2020; 27(1): 1218 | | [Pubmed] | [DOI] | | | 124 |
NIR-II Dual-Modal Optical Coherence Tomography and Photoacoustic Imaging-Guided Dose-Control Cancer Chemotherapy |
|
| Yubin Liu,Mengze Xu,Yunlu Dai,Qi Zhao,Lipeng Zhu,Xiaowen Guan,Gang Li,Sihua Yang,Zhen Yuan | | ACS Applied Polymer Materials. 2020; | | [Pubmed] | [DOI] | | | 125 |
Preparation and evaluation of inhalable dry powder containing glucosamine-conjugated gefitinib SLNs for lung cancer therapy |
|
| Nazafarin Satari,Somayeh Taymouri,Jaleh Varshosaz,Mahboubeh Rostami,Mina Mirian | | Drug Development and Industrial Pharmacy. 2020; : 1 | | [Pubmed] | [DOI] | | | 126 |
Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications |
|
| Kuldeep Rajpoot | | Current Cancer Drug Targets. 2020; 20(4): 271 | | [Pubmed] | [DOI] | | | 127 |
Orally Administered Nanotherapeutics For Parkinson’s Disease: An Old Delivery System Yet More Acceptable |
|
| Nidhi Aggarwal,Zufika Qamar,Saleha Rehman,Sanjula Baboota,Javed Ali | | Current Pharmaceutical Design. 2020; 26(19): 2280 | | [Pubmed] | [DOI] | | | 128 |
Development and characterisation of a novel krill oil nanostructured lipid carrier based on 1,3-glycerol distearate |
|
| Yunwei Lin,Wenting Yin,Guoqin Liu | | International Journal of Food Science & Technology. 2020; | | [Pubmed] | [DOI] | | | 129 |
Preparation of Ergosterol-Loaded Nanostructured Lipid Carriers for Enhancing Oral Bioavailability and Antidiabetic Nephropathy Effects |
|
| Zhonghua Dong,Sajid Iqbal,Zhongxi Zhao | | AAPS PharmSciTech. 2020; 21(2) | | [Pubmed] | [DOI] | | | 130 |
Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages |
|
| Parisa Ghasemiyeh,Soliman Mohammadi-Samani | | Drug Design, Development and Therapy. 2020; Volume 14: 3271 | | [Pubmed] | [DOI] | | | 131 |
Recent Advances in Designing 5-Fluorouracil Delivery Systems: A Stepping Stone in the Safe Treatment of Colorectal Cancer |
|
| Elaheh Entezar-Almahdi,Soliman Mohammadi-Samani,Lobat Tayebi,Fatemeh Farjadian | | International Journal of Nanomedicine. 2020; Volume 15: 5445 | | [Pubmed] | [DOI] | | | 132 |
Oral Nano Drug Delivery Systems for the Treatment of Type 2 Diabetes Mellitus: An Available Administration Strategy for Antidiabetic Phytocompounds |
|
| Xin Nie,Zhejie Chen,Lan Pang,Lin Wang,Huajuan Jiang,Yi Chen,Zhen Zhang,Chaomei Fu,Bo Ren,Jinming Zhang | | International Journal of Nanomedicine. 2020; Volume 15: 10215 | | [Pubmed] | [DOI] | | | 133 |
A new agent for the treatment of lung cancer: B13 loaded solid lipid nanoparticles |
|
| Emre Çömlekçi,Hatice Mehtap Kutlu,Canan Vejselova Sezer | | Advances in Natural Sciences: Nanoscience and Nanotechnology. 2020; 11(4): 045014 | | [Pubmed] | [DOI] | | | 134 |
Challenges identifying efficacious miRNA therapeutics for cancer |
|
| Meirav Segal,Frank J. Slack | | Expert Opinion on Drug Discovery. 2020; : 1 | | [Pubmed] | [DOI] | | | 135 |
Carbonate Apatite and Hydroxyapatite Formulated with Minimal Ingredients to Deliver SiRNA into Breast Cancer Cells In Vitro and In Vivo |
|
| Rowshan Ara Islam,Hamed Al-Busaidi,Rahela Zaman,Syafiq Asnawi Zainal Abidin,Iekhsan Othman,Ezharul Hoque Chowdhury | | Journal of Functional Biomaterials. 2020; 11(3): 63 | | [Pubmed] | [DOI] | | | 136 |
Nano targeted Therapies Made of Lipids and Polymers have Promising Strategy for the Treatment of Lung Cancer |
|
| Marwa Labib Essa,Maged Abdeltawab El-Kemary,Eman Mohammed Ebrahem Saied,Stefano Leporatti,Nemany Abdelhamid Nemany Hanafy | | Materials. 2020; 13(23): 5397 | | [Pubmed] | [DOI] | | | 137 |
Hydroxysafflor Yellow A: A Systematical Review on Botanical Resources, Physicochemical Properties, Drug Delivery System, Pharmacokinetics, and Pharmacological Effects |
|
| Feng Zhao,Ping Wang,Yuanyuan Jiao,Xiaoxiao Zhang,Daquan Chen,Haiyu Xu | | Frontiers in Pharmacology. 2020; 11 | | [Pubmed] | [DOI] | | | 138 |
Formulation and Development of Transferrin Targeted Solid Lipid Nanoparticles for Breast Cancer Therapy |
|
| Geeta S. Bhagwat,Rajani B. Athawale,Rajeev P. Gude,Shadab Md,Nabil A. Alhakamy,Usama A. Fahmy,Prashant Kesharwani | | Frontiers in Pharmacology. 2020; 11 | | [Pubmed] | [DOI] | | | 139 |
Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review |
|
| Zeinab Nouri,Marziyeh Hajialyani,Zhila Izadi,Roodabeh Bahramsoltani,Mohammad Hosein Farzaei,Mohammad Abdollahi | | Frontiers in Bioengineering and Biotechnology. 2020; 8 | | [Pubmed] | [DOI] | | | 140 |
Nanoparticle-Mediated Drug Delivery for Treatment of Ischemic Heart Disease |
|
| Chengming Fan,Jyotsna Joshi,Fan Li,Bing Xu,Mahmood Khan,Jinfu Yang,Wuqiang Zhu | | Frontiers in Bioengineering and Biotechnology. 2020; 8 | | [Pubmed] | [DOI] | | | 141 |
Nanoparticle Formulations of Poly (ADP-ribose) Polymerase Inhibitors for Cancer Therapy |
|
| Bijay Singh,Shicheng Yang,Apurva Krishna,Srinivas Sridhar | | Frontiers in Chemistry. 2020; 8 | | [Pubmed] | [DOI] | | | 142 |
Formulation Strategies to Improve Oral Bioavailability of Ellagic Acid |
|
| Guendalina Zuccari,Sara Baldassari,Giorgia Ailuno,Federica Turrini,Silvana Alfei,Gabriele Caviglioli | | Applied Sciences. 2020; 10(10): 3353 | | [Pubmed] | [DOI] | | | 143 |
Novel biomimetic nanostructured lipid carriers for cancer therapy: preparation, characterization, and in vitro/in vivo evaluation |
|
| Jianwen Zhou,Biru Guo,Wenquan Zhu,Xiaoyu Sui,Xiaoxing Ma,Jiayi Qian,Lixin Cao,Cuiyan Han | | Pharmaceutical Development and Technology. 2020; : 1 | | [Pubmed] | [DOI] | | | 144 |
Nanolipoidal a-terpineol modulates quorum sensing regulated virulence and biofilm formation in Pseudomonas aeruginosa |
|
| Sunil Kumar Bose,Pradip Nirbhavane,Mahak Batra,Sanjay Chhibber,Kusum Harjai | | Nanomedicine. 2020; 15(18): 1743 | | [Pubmed] | [DOI] | | | 145 |
Nanocarriers as Magic Bullets in the Treatment of Leukemia |
|
| Mohammad Houshmand,Francesca Garello,Paola Circosta,Rachele Stefania,Silvio Aime,Giuseppe Saglio,Claudia Giachino | | Nanomaterials. 2020; 10(2): 276 | | [Pubmed] | [DOI] | | | 146 |
Formulation Strategies for Enhancing the Bioavailability of Silymarin: The State of the Art |
|
| Alfonso Di Costanzo,Ruggero Angelico | | Molecules. 2019; 24(11): 2155 | | [Pubmed] | [DOI] | | | 147 |
Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives |
|
| Claudio J. Ketabat,Claudio J. Pundir,Claudio J. Mohabatpour,Claudio J. Lobanova,Claudio J. Koutsopoulos,Claudio J. Hadjiiski,Claudio J. Chen,Claudio J. Papagerakis,Claudio J. Papagerakis | | Pharmaceutics. 2019; 11(7): 302 | | [Pubmed] | [DOI] | | | 148 |
Anti-Angiogenic Effect of Orally Available Pemetrexed for Metronomic Chemotherapy |
|
| V. V. S. Narayan Reddy Maharjan,V. V. S. Narayan Reddy Pangeni,V. V. S. Narayan Reddy Jha,V. V. S. Narayan Reddy Choi,V. V. S. Narayan Reddy Chang,V. V. S. Narayan Reddy Choi,V. V. S. Narayan Reddy Park,V. V. S. Narayan Reddy Byun | | Pharmaceutics. 2019; 11(7): 332 | | [Pubmed] | [DOI] | | | 149 |
Lipid Delivery Systems for Nucleic-Acid-Based-Drugs: From Production to Clinical Applications |
|
| Anna Angela Barba,Sabrina Bochicchio,Annalisa Dalmoro,Gaetano Lamberti | | Pharmaceutics. 2019; 11(8): 360 | | [Pubmed] | [DOI] | | | 150 |
Comparative effects of nanoemulsions loaded with duck oil and lard oil on palmitate-induced lipotoxicity |
|
| Eun Sil Kang,Jinwoo Hur,Yoenji Jo,Hyo Juong Kim,Sung Gu Han,Han Geuk Seo | | Journal of Food Biochemistry. 2019; | | [Pubmed] | [DOI] | | | 151 |
Nutraceuticals’ Novel Formulations: The Good, the Bad, the Unknown and Patents Involved |
|
| Nada A. Helal,Heba A. Eassa,Ahmed M. Amer,Mohamed A. Eltokhy,Ivan Edafiogho,Mohamed I. Nounou | | Recent Patents on Drug Delivery & Formulation. 2019; 13(2): 105 | | [Pubmed] | [DOI] | | | 152 |
Cyproterone acetate-loaded nanostructured lipid carriers: effect of particle size on skin penetration and follicular targeting |
|
| Parisa Ghasemiyeh,Amir Azadi,Saeid Daneshamouz,Reza Heidari,Negar Azarpira,Soliman Mohammadi-Samani | | Pharmaceutical Development and Technology. 2019; : 1 | | [Pubmed] | [DOI] | | | 153 |
Formulation and optimization of intranasal nanolipid carriers of pioglitazone for the repurposing in Alzheimer’s disease using Box-Behnken design |
|
| Gifty M. Jojo,Gowthamarajan Kuppusamy,Anindita De,V. V. S. Narayan Reddy Karri | | Drug Development and Industrial Pharmacy. 2019; : 1 | | [Pubmed] | [DOI] | | | 154 |
Recent advances in metallopolymer-based drug delivery systems |
|
| Gulzhian I. Dzhardimalieva,Lev N. Rabinskiy,Kamila A. Kydralieva,Igor E. Uflyand | | RSC Advances. 2019; 9(63): 37009 | | [Pubmed] | [DOI] | | | 155 |
Analyzing Nanotheraputics-Based Approaches for the Management of Psychotic Disorders |
|
| Malay Annu,Saleha Rehman,Shadab Md,Sanjula Baboota,Javed Ali | | Journal of Pharmaceutical Sciences. 2019; | | [Pubmed] | [DOI] | | | 156 |
Brain targeting of Baicalin and Salvianolic acid B combination by OX26 functionalized nanostructured lipid carriers |
|
| Yumei Wu,Xunan Song,Dereje Kebebe,Xinyue Li,Zhifeng Xue,Jiawei Li,Shouying Du,Jiaxin Pi,Zhidong Liu | | International Journal of Pharmaceutics. 2019; : 118754 | | [Pubmed] | [DOI] | | | 157 |
Engineered nano scale formulation strategies to augment efficiency of nutraceuticals |
|
| Asad Ali,Usama Ahmad,Juber Akhtar,Juber Badruddeen,Mohd Muazzam Khan | | Journal of Functional Foods. 2019; 62: 103554 | | [Pubmed] | [DOI] | | | 158 |
Phthalocyanine-loaded nanostructured lipid carriers functionalized with folic acid for photodynamic therapy |
|
| João A. Oshiro-Júnior,Mariana Rillo Sato,Fernanda Isadora Boni,Karen Loraine Macena Santos,Kleber Thiago de Oliveira,Laura Marise de Freitas,Carla Raquel Fontana,Dean Nicholas,Anthony McHale,John F. Callan,Marlus Chorilli | | Materials Science and Engineering: C. 2019; : 110462 | | [Pubmed] | [DOI] | | | 159 |
Nanoparticles and its biomedical applications in health and diseases: special focus on drug delivery |
|
| Nuzhat Zahin,Raihanatul Anwar,Devesh Tewari,Md. Tanvir Kabir,Amin Sajid,Bijo Mathew,Md. Sahab Uddin,Lotfi Aleya,Mohamed M. Abdel-Daim | | Environmental Science and Pollution Research. 2019; | | [Pubmed] | [DOI] | | | 160 |
Nanocarriers for effective delivery of benznidazole and nifurtimox in the treatment of chagas disease: A review |
|
| Eva C. Arrúa,Katia P. Seremeta,Giselle R. Bedogni,Nora B. Okulik,Claudio J. Salomon | | Acta Tropica. 2019; 198: 105080 | | [Pubmed] | [DOI] | | | 161 |
Nanoemulsions improve the efficacy of turmeric in palmitate- and high fat diet-induced cellular and animal models |
|
| Eun Ji Lee,Jung Seok Hwang,Eun Sil Kang,Su Bi Lee,Jinwoo Hur,Won Jin Lee,Mi-Jung Choi,Jun Tae Kim,Han Geuk Seo | | Biomedicine & Pharmacotherapy. 2019; 110: 181 | | [Pubmed] | [DOI] | | | 162 |
Colombian propolis as starting material for the preparation of nanostructured lipid carriers |
|
| Yuly X. Correa González,Alba L. Valenzuela Correa,Ángel M. Ardila Vargas,Maritza A. Rojas Cardozo,Claudia E. Mora Huertas | | Revista Brasileira de Farmacognosia. 2019; | | [Pubmed] | [DOI] | | | 163 |
Cytotoxicity screening of emulsifiers for pulmonary application of lipid nanoparticles |
|
| Verena Steiner,Kristin Öhlinger,Carolina Corzo,Sharareh Salar-Behzadi,Eleonore Fröhlich | | European Journal of Pharmaceutical Sciences. 2019; 136: 104968 | | [Pubmed] | [DOI] | | | 164 |
An Overview of the Role of Nanoparticles in Handling the Breast Cancer |
|
| Roghayeh Abbasalipourkabir,Nasrin Ziamajidi | | Avicenna Journal of Medical Biochemistry. 2019; 7(1): 1 | | [Pubmed] | [DOI] | | | 165 |
Solid lipid nanoparticles and nanostructured lipid carriers: A review emphasizing on particle structure and drug release |
|
| Aldemar Gordillo-Galeano,Claudia Elizabeth Mora-Huertas | | European Journal of Pharmaceutics and Biopharmaceutics. 2018; 133: 285 | | [Pubmed] | [DOI] | | | 166 |
Improved delivery of voriconazole to Aspergillus fumigatus through solid lipid nanoparticles as an effective carrier |
|
| Hamid Reza Kelidari,Roghayeh Babaei,Mojtaba Nabili,Tahereh Shokohi,Majid Saeedi,Sara Gholami,Maryam Moazeni,Ali Nokhodchi | | Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2018; 558: 338 | | [Pubmed] | [DOI] | | | 167 |
Surface modified kokum butter lipid nanoparticles for the brain targeted delivery of nevirapine |
|
| Sunita Lahkar,Malay Kumar Das | | Journal of Microencapsulation. 2018; 35(7-8): 680 | | [Pubmed] | [DOI] | |
|
 |
|
|
|
Search Pubmed for