Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 211
  • Home
  • Print this page
  • Email this page
Year : 2019  |  Volume : 14  |  Issue : 6  |  Page : 566-573

Naringenin potentiated β-sitosterol healing effect on the scratch wound assay

1 Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, 19328, Amman, Jordan
2 Faculty of Pharmacy, Al-Ahliyya Amman University, 19328, Amman, Jordan

Correspondence Address:
Manal Ahmad Abbas
Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, 19328, Amman
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1735-5362.272565

Rights and Permissions

In the present investigation scratch wound assay was used to study the ability of several combinations of each flavonoid (chrysin, naringenin or resveratrol) with β-sitosterol to heal wounds in vitro. MTT test was performed to determine if the combination of flavonoid with β-sitosterol was toxic to fibroblasts or not. Also, superoxide dismutase (SOD) activity and interleukin-1ß (IL-1β) concentrations were measured. The best closure rates were obtained with β-sitosterol combined with naringenin and β-sitosterol combined with resveratrol. The combination that produced the best closure rate namely β-sitosterol with naringenin increased SOD activity significantly. However, this combination was not better than naringenin or β-sitosterol alone in reducing IL-β concentration. The results of MTT test indicated that the combination as well as β-sitosterol alone or naringenin alone has no toxic effect on fibroblasts. In conclusion, the combination of β-sitosterol and naringenin exerted a synergistic effect on wound closure without decreasing the viability of fibroblasts, increased antioxidant defense mechanism and decreased IL-β.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded369    
    Comments [Add]    
    Cited by others 14    

Recommend this journal