| ORIGINAL ARTICLE |
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| Year : 2021 | Volume
: 16
| Issue : 1 | Page : 71-78 |
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Protective effects of a standardized extract of Iris germanica on pancreas and liver in streptozotocin-induced diabetic rats
Mohammad Reza Mahdinezhad1, Sara Hooshmand2, Mohammad Soukhtanloo1, Shirin Taraz Jamshidi3, Sajad Ehtiati1, Ahmad Ghorbani2
1 Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, I.R. Iran
2 Pharmacological Research Center of Medicinal Plants; Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, I.R. Iran
3 Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, I.R. Iran
Correspondence Address:
Ahmad Ghorbani
Pharmacological Research Center of Medicinal Plants; Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad
I.R. Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1735-5362.305190
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Background and purpose: Previous studies have shown the antioxidant, anti-inflammatory, immunomodulatory, and hypolipidemic activities of Iris germanica. The aim of the present study was to evaluate the protective effects of hydroalcoholic extract of Iris germanica rhizomes on streptozotocin-induced diabetic rats.
Experimental approach: Twenty-four male Wistar rats were randomly assigned into four groups including a normal control group, diabetic control group, diabetic groups treated for 4 weeks with 100 and 200 mg/kg/day of the Iris germanica extract (IGE).
Findings/Results: Induction of diabetes significantly decreased the body weight gain and considerably increased the serum levels of glucose, triglyceride, blood urea nitrogen (BUN), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Diabetes also diminished the antioxidant capacity of the liver (decrease of thiol groups) and significantly degenerated pancreatic islands. The IGE at both doses of 100 and 200 mg/kg significantly reduced the levels of glucose, triglyceride, AST, ALT, and ALP. Moreover, IGE increased the total antioxidant capacity of the liver and ameliorated pancreatic island morphology. The extract had no significant effect on body weight and BUN level.
Conclusion and implication: These findings suggest that Iris germanica rhizomes inhibits the progression of hyperglycemia and hypertriglyceridemia and has protective effects against diabetes-induced injury of the liver and pancreas. Therefore, this plant has the potential to be used as a natural product for controlling diabetes.
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