Figure 3: Comparison of (A) Sirt1 and (B) Nrf2 genes expression in liver tissues of groups of controls, diabetic, diabetic, and normal rats fed with Co Q10 (10 mg/kg BW for 6 weeks) using quantitative RT-PCR. The results were normalized against the expression of the housekeeping gene, Cyclo A. Co Q10 treatment considerably increased Sirt1 and Nrf2 genes expression compared diabetic group. * Represents a significant difference between diabetic group and control groups (P < 0.05) and # indicates a significant difference between diabetic rats received Co Q10 and diabetic group. Values are means ± SEM for each group. Each bar represents at least six rats. RT-PCR, Real time polymerase chain reaction; Co Q10, coenzyme Q10; DM, diabetes mellitus.