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  Indian J Med Microbiol
 

Figure 4: The effects of biotin on the development of neuropathic pain. The effect of chronic treatment with biotin (4, 8, and 16 mg/kg; p.o.) from 1st day to the 21st day after surgery on the development of (A) heat hyperalgesia, (B) cold allodynia, and (C) mechanical allodynia. The CCI groups received saline solution according to the treatment schedule. The results are expressed as mean ± SEM, n = 8. #P < 0.05, ##P < 0.01, and ###P < 0.001 indicate significant differences versus the CCI group. CCI, chronic constriction injury

Figure 4: The effects of biotin on the development of neuropathic pain. The effect of chronic treatment with biotin (4, 8, and 16 mg/kg; p.o.) from 1<sup>st</sup> day to the 21<sup>st</sup> day after surgery on the development of (A) heat hyperalgesia, (B) cold allodynia, and (C) mechanical allodynia. The CCI groups received saline solution according to the treatment schedule. The results are expressed as mean ± SEM, n = 8. <sup>#</sup><i>P</i> < 0.05, <sup>##</sup><i>P</i> < 0.01, and <sup>###</sup><i>P</i> < 0.001 indicate significant differences versus the CCI group. CCI, chronic constriction injury