Figure 2: Effect of methamphetamine and TQ on the (A) total and (B) central locomotion in the open field test. Mice received intraperitoneal methamphetamine (10 mg/kg) four times a day in 2-h intervals and TQ at 5, 10, and 20 mg/kg, 30 min before each METH injection. The results are presented as mean ± SEM, n = 6. **P < 0.01 and ***P < 0.001 indicate significant differences compared to the control group; and #P < 0.05, ##P < 0.01, and ###P < 0.001 against the vehicle + methamphetamine group. The median of groups was analyzed by Kruskal-Wa Wallis followed by the Dunn test. TQ, Thymoquinone.